Browsing by Author "Chandrasiri, W.A.L."

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Ayurveda: The current issues and challenges
(Gampaha Wickramarachchi Ayurveda Institute, 2006) Amarasekara, A.A.D.; Chandrasiri, W.A.L.
A case report on selected herbal decoction in improving physical and psychological conditions of a patient with Benign Intracranial Hypertension (BIH)
(Gampaha Wickramarachchi Ayurveda Institute, 2012) Chandrasiri, W.A.L.; Adhikari, A.M.C.J.; Chandrakanthi, R.U.; Wewalwala, S.L.; de Mel, W.K.G.
Effect of a decoction in improving platelet count and clinical conditions of a patient with Idiopathic Thrombocytopenic Purpura (ITP): A case report
(Gampaha Wickramarachchi Ayurveda Institute, 2012) Chandrasiri, W.A.L.; Adhikari, A.M.C.J.; Chandrakanthi, R.U.; Wewalwala, S.L.; de Mel, W.K.G.
Effect of long term administration of DML10 - a polyherbal formulation on serum glucose levels, serum lipid levels and haematological indices in dietary induced hyperlipidaemic rats
(Research Symposium 2010 - Faculty of Graduate Studies, University of Kelaniya, 2010) Chandrasiri, W.A.L.; Pathiratne, A.
This study evaluated the effect of long term administration of a polyherbal formulation (DML10) consisting of 12 medicinal plant materials, on serum glucose levels, serum lipid levels and haematological indices in dietary induced hyperlipidaemic rats. Wistar albino rats were made hyperlipidaemic by feeding cholesterol rich diet continuously for one month and same diet was continued during the period of experiment. Selected rats were randomly divided into four groups (n=10). The test group was treated daily with DML10 (10.8 ml/kg/day; strength: 65±0.54mg/ml in dry weight of the decoction) orally for 90 consecutive days. Two positive control groups were treated orally with Simvastatin (0.9 mg/kg/day) or Fenofibrate (18 mg/kg/day) separately where as the placebo group received only comparable volumes of distilled water during the 90 days period. Serum glucose levels and lipid levels and haematological indices of the rats were determined using standard methods. All rats showed significant increase in fasting glucose level and fasting total cholesterol level after feeding with cholesterol rich diet for one month. After 90 days of the treatment, the fasting serum glucose levels of the rats treated with DML10, Simvastatin and Fenofibrate were significantly decreased by 51%, 29% and 23% respectively in comparison to that of placebo group. Serum triglyceride level of the DML10 treated rats was decreased significantly by 59% of the level of placebo group where as Simvastatin or Finofibrate administration resulted only 42% and 47% decrease in triglyceride levels respectively. DML10 treatment had no significant effect on serum HDL levels but serum total cholesterol and LDL levels were decreased significantly by 54% and 60% respectively in comparison to those of placebo group. Simvastatin group showed 64%, and 82.5% decrease in same parameters and Fenofibrate group showed 56% and 69% decrease respectively. Serum HDL levels were significantly increased in Simvastatin group (35%) and Fenofibrate group (31%). Test and positive control groups showed no significant changes in primary and secondary erythrocytic indices, total leucocyte counts and platelet counts in the blood and hepatic enzyme activities and creatinine levels in the serum compared to those of placebo group. The results revealed that long term administration of DML10 could decrease fasting lipid levels (except HDL) and fasting glucose levels in the sera of dietary induced hyperlipidaemic rats without affecting the haematological parameters.
Effect of polyherbal formulation DM 13 in the management of Diabetes Mellitus Type 2 (DMT2) patients treated with Glybenclamide and Metformin- A retrospective cohort study
(Sabaragamuwa University of Sri Lanka, 2006) Chandrasiri, W.A.L.; Chandrasekara, H.I.; Fernando, W.S.
Effect of Yawanadi khanda in improving low body weight, loss of appetite and recurrence of common cold in school children
(Gampaha Wickramarachchi Ayurveda Institute, 2012) Priyangika, R.K.N.; Chandrasiri, W.A.L.; Abegunawardhana, M.D.J.; Jayarathna, S.K.H.C.
Efficacy of a novel formulation of medicinal plants in managing experimentally induced hyperglycaemic and hyperlipidaemic condition in rat models
(University of Kelaniya, 2015) Chandrasiri, W.A.L.
Evaluation of the effect of a polyherbal formulation (DML10) on key hepatic enzymes and serum creatinine
(Gampaha Wickramarachchi Ayurveda Institute, 2009) Chandrasiri, W.A.L.; Pathiratne, A.; Priyangika, R.K.N.
Evaluation of the effect of a polyherbal formulation (DMLl10) on serum glucose levels and lipid levels in rats
(University of Kelaniya, 2008) Chandrasiri, W.A.L.; Pathiratne, A.
The objective of present study was to evaluate the effects of a polyherbal formulation (DML10) consisting of 12 medicinal plant materials on serum glucose and lipid levels in rats. Three different concentrations of decoctions of DML 10 (low dose: 32 ± 0.4 mg/ml, mid dose: 65 ± 0.54 mg/ml, high dose: 124 ± 0.93 mg/ml in dry weight of the decoction) were orally administered to three different groups of apparently healthy Wistar rats at the dose of 10.8 ml/kg body weight/day (as a single dose) for 14 consecutive days. The comparable control group received the same amount of distilled water for 14 consecutive days (n =10 for each group). Two weeks prior to the treatment and 14 days after the treatment serum glucose levels and lipid levels were determined using standard methods. All rats were found to be normoglycaemic and normolipidaemic prior to the treatment. The fasting serum glucose level of the rats treated with mid dose of decoction was significantly decreased by 27% in comparison to the control group. Serum triglyceride levels and cholesterol levels of the rats treated with three doses were decreased by 6 - 4 7% and 6 - 16% respectively in comparison to the controls in a concentration dependent manner. Depletion of lipid levels was significant in rats treated with the mid and high doses of the decoctions. The results revealed that the short term treatment of mid dose of DML10 could reduce the fasting serum glucose levels while both mid and high doses of DML10 were potent enough to reduce serum triglyceride and cholesterol levels in the treated rats.
Evaluation of the effect of a water extract of Alstonia scholaris leaves on serum glucose levels in rats
(Gampaha Wickramarachchi Ayurveda Institute, 2009) Marasinghe, M.N.S.; Chandrasiri, W.A.L.; Priyangika, R.K.N.; Karunarathna, D.A.P.C.; Fernando, K.P.M.W.D.A.M.A.
Evaluation of the effect of an Ayurveda regime on fasting blood glucose level of diabetes Mellitus Type 2 Patients Withdrawn Conventional Treatments: A Retrospective study
(Pandit G.P. Wickramarochchi Memorial International Research Symposium – 2012, 2012) Chandrasiri, W.A.L.; Dissanayaka, K.G.C.; Adhikari, A.M.C.J.; Chandrakanthi, R.U.; Wewalwala, S.L.; De Mel, W.K.G.
Diabetes mellitus type 2 (DMT2) is the commonest from of diabetes and it is due to insulin resistance or relative insulin deficiency. This is a multifactorial disorder involving environmental and strong genetic factors. At present its worldwide prevalence is increasing and as a chronic progressive disorder its incidence increase with age. This study was designed to evaluate the effect of a selected Ayurveda regime on Fasting Blood Sugar (FBS) level of DMT2 patients. 370 case records of previously knownDMT2 patient for last 12 months were obtained from the diabetic clinic of Gampaha Wickramarachchi Ayurveda Hospital. Cases related wit(l Heart diseases, Hyperllpldaemia, Kidney diseases, Bronchial asthma and Hypertension were excluded. 35 cases from above patients who had 01-02 months of withdrawal from previous conventional treatments, (Allopathic, Ayurveda, Indigenous medicine, etc.) and had taken the regime for at least one month were selected. The regime consisted of a herbal decoction (1M), a tablet (Chandrapraba vati) and a mixture of two herbal powders (Hingvashtaka curna and Bashkara lavana curna). Data related to laboratory investigations of FBS which have been taken within period of 4 weeks. They were divided into two parts to interpret the result after two weeks and four weeks separately. 88.57% of the selected cases indicated a decrement of FBS level, 8.57% indicated an elevation of the FBS and 2 86% indicated no significant change 4 weeks after treatments_ Mean decrement of FBS level after 02 weeks was 24.37% and 31.07 % of decrement showed after 04 weeks. It can concluded that the regime had shown beneficial effect in controlling the FBS level in DMT2 patients & further studies should be carried out.
Hypoglycaemic and hypolipidaemic activities of a polyherbal formulation (DML 10) in dietary induced hyperlipidaemic rats
(Research Symposium 2009 - Faculty of Graduate Studies, University of Kelaniya, 2009) Chandrasiri, W.A.L.; Pathiratne, A.
The present study was conducted to evaluate the effect of a polyherbal formulation (DML10) consisting of 12 medicinal plant materials on serum glucose levels and serum lipid levels in dietary induced hyperlipidaemic rats. Wistar albino rats were made hyperlipidaemic by giving cholesterol rich diet for one month and same diet was continued during the period of experiment. They were randomly divided into four groups (n=10) and one group was orally administered with DML10 (10.8 ml/kg/day; strength: 65±0.54mg/ml in dry weight of the decoction) for 14 consecutive days. Two groups (positive control groups) received Simvastatin (0.9 mg/kg/day) or Fenofibrate (18 mg/kg/day) orally and the placebo group received only comparable volumes of distilled water for 14 consecutive days. Serum glucose levels and lipid levels were determined using standard methods. All rats showed significant increase in fasting glucose level and fasting total cholesterol level after feeding with cholesterol rich for one month. The fasting glucose level of the test group treated with DML 10 was significantly decreased by 25% in comparison to the placebo control group. The positive control groups which received Simvastatin showed no significant decrease in fasting glucose level while Fenofibrate showed a significant decrease (14%) in fasting glucose level. Total cholesterol, triglyceride and LDL levels in the sera of the group treated with DML10 were reduced to 33%, 54% and 67% of the placebo control group whereas corresponding decreases in the sera of positive control groups were 38-39%, 36% and 52-77% respectively. The result revealed that short term administration of DML 10 could reduce fasting glucose levels and fasting lipid levels (except HDL) in the sera of dietary induced hyperlipidaemic rats.
Prameha: The characteristics in abnormal urine in comparison to the modern perspectives
(Gampaha Wickramarachchi Ayurveda Institute, 2006) Chandrasiri, W.A.L.