Browsing by Author "Herath, R.P."

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Antenatal uterine rupture in a pregnancy following microwave endometrial ablation
(Informa Healthcare, 2011) Herath, R.P.; Singh, N.; Oligbo, N.
No abstract available
Antimicrobials in Gynaecological practice
(Sri Lanka college of Obstetricians & Gynaecologists, 2017) Patabendige, M.; Herath, R.P.; Wijesooriya, W.R.P.L.I.
Surgical site infections are a common complication of Gynaecological surgeries. Up to 8-10% of Gynaecological patients undergoing an operative procedure will develop a surgical site infection. In surgeries with high rates of post-operative infection, antibiotic prophylaxis can play a major role in improving outcomes. In addition there are many indications where antimicrobial treatment is necessary in day-to-day Gynaecological practice. This review summarizes the available medical literature to assess the indications and appropriate antimicrobials for common circumstances in Gynaecological practice.
Blood flow changes in pelvic vessels associated with the application of an abdominal compression belt in healthy postpartum women
(Sri Lanka Medical Association, 2017) Dias, T.; Patabendige, M.; Herath, R.P.; Garvik, T.I.; Liland, F.; Arulkumaran, S.
INTRODUCTION: Postpartum haemorrhage (PPH) accounts for a high proportion of maternal mortality and morbidity throughout the world. A uterine compression belt which has been developed recently represents a very low tech, low cost solution in managing postpartum haemorrhage. OBJECTIVES :To evaluate the blood flow changes in pelvic vessels following application of the postpartum haemorrhage compression belt (Laerdal Global Health, Stavanger, Norway). METHODS: The sample included healthy postpartum women within 6 hours of vaginal delivery. The study was performed at Teaching Hospital, Ragama, Sri Lanka. PPH compression belt was applied on the lower abdomen in a supine position with a slight lateral tilt. Patient’s pulse, blood pressure and Doppler indices (RI, PI and PFV) of the uterine, internal iliac and femoral arteries were measured using transabdominal Doppler ultrasonography. Lower limb oxygen saturation was also measured. Measurements were obtained by connecting the subjects to a multimonitor throughout the study period of 20 minutes. Median RI, PI and PFV was calculated and comparisons were made between the baseline and after belt application at 10 and 20 minutes. RESULTS: A total of 20 healthy women were included and the mean time from delivery to study inclusion was 2.5 (range 0.5–5.0) hours. There were no adverse outcomes or altered vital signs noted among participants. Overall there were no significant changes in the internal iliac, uterine and femoral artery blood flow after application of the compression belt. CONCLUSIONS: There were no significant changes in the internal iliac, uterine and femoral artery blood flow after application of the compression belt. This preliminary study only shows that the application of the PPH compression belt has no apparent adverse changes in the iliac, uterine and femoral artery blood flow in postpartum mothers.
A case of labial adhesions following primary genital herpes infection
(Sri Lanka College of Obstetricians & Gynaecologists, 2018) Casather, D.M.; Herath, R.P.; Ranathunga, R.D.J.; Pannala, W.S.
INTRODUCTION: Genital Herpes is one of the common sexually transmitted diseases in Sri Lanka. Although, the labial adhesions usually associated with hypo-oestrogenism, it may occur as a rare complication of Genital Herpes infection. Here we present a case of almost complete thick band labial adhesions following Genital Herpes infection. Case Report: A 23 year old nulliparous woman presented with vulval pain, dysuria and fever for two days. On vulval examination she had extensive, multiple, painful genital ulcers with some blistering lesions over both labia majora and minora. She had been in a monogamous relationship with the partner, with last sexual exposure about 10 days prior to the development of ulcers. Presumptive diagnosis of primary genital herpes was made on clinical manifestations. She was treated with 7 days course of oral Acyclovir. Ten days later she presented with a complaint of narrowing of the vaginal introitus and dysuria. On examination vulval lesions were in the partial remission and there was thick band of adhesion on the upper two third of labia minora with multiple scars of healing ulcers on either side. Manual separation of adhesions was not attempted due to tense nature of the adhesions. Surgical separation of labial adhesions was done under general anesthesia. After two weeks she made complete remission of Genital herpes ulcers and there were no further labial adhesions. A further follow up appointment was arranged in three months. DISCUSSION: Labial adhesions are not common among women in reproductive age who are having well oestrogenised vulva, in comparison to prepubertal and postmenopausal women with less oestrogenised vulva. Labial adhesions are rare, but severe form of local complication of genital herpes infection. The formation of labial adhesions can be prevented by early treatment with adequate dose of oral acyclovir. Gentle application of local anaesthetic over the labia minora alleviates pain and prevents labial adhesions formation in patients with genital herpes. The usual solution for adult labial adhesion following genital herpes infection is surgical adhesiolysis. Manual separation of the labia under application of local anaesthesia can be considered in patients who have less dense adhesions. This is the first published material in Sri Lanka on this matter. The importance of this report is to maintain the vigilance among health care providers about this rare complication as Genital Herpes infection is a very common sexually transmitted infection in Sri Lanka.
A Case of labial adhesions following primary genital herpes infection
(Kandy Society of Medicine, 2018) Casather, D.M.; Herath, R.P.; Ranathunga, R.D.J.; Pannala, W.S.
Labial adhesions are usually associated with hypo-oestrogenism, but it is also a rare complication of genital herpes infection. We present a case report of a 23-year-old woman presenting with primary genital herpes infection, progressing to labial adhesions.
A case of pulmonary endometriosis treated by bronchial angiographic embolization
(Sri Lanka College of Obstetricians & Gynaecologists, 2018) Casather, D.M.; Herath, R.P.; Sanjeewa, J.M.P.; Sandaruwan, N.K.T.S.; Ganewatte, E.
INTRODUCTION: Although usually confined to the pelvis, endometriosis can be found in extra-pelvic organs and tissues as well. One of the rare forms of extra-pelvic endometriosis is thoracic endometriosis (TE). It is characterized by presence of functional endometrial tissues within the pleura, in the lung parenchyma or the airway. We present a case of TE managed with bronchial angiographic embolization (BAE). CASE REPORT: A 32-year-old woman with two children presented with repetitive catamenial haemoptysis for 8 months’ duration Haemoptysis usually started on the first day or the second day of each menstruation and it continued for 5 to 6 days and it was identical with the menstrual interval. She had one vaginal delivery and one caesarean section 10 years ago and 6 years ago respectively. Two years ago, she had diagnostic laparoscopy for chronic pelvic pain and which revealed pelvic endometriosis. Her medical history was otherwise unremarkable. Physical examination of the respiratory system was normal. Chest X-ray had symmetrical thorax and plain lung markings without abnormal findings. A chest computed tomography taken during the menstruation revealed a focal consolidation with adjacent ground glass opacification in the basal segment of the right lower lobe. Since, haemoptysis spontaneously resolved with the menstruation we assumed this catamenial haemoptysis due to pulmonary endometriosis and planed for BAE. During the procedure ultrasound guided diagnostic descending aortogram was performed using a catheter placing in the proximal descending thoracic aorta. Angiogram revealed a hyperaemic area in the lower lobe of the right lung, supplied by the hypertrophied lower lobe branch of right intercosto-bronchial artery. Super selective cauterization and embolization of the feeding right bronchial artery was done with PVA particles. Post embolization angiogram revealed satisfactory occlusion of the arterial supply to the hyperaemic area. Post procedure course was uneventful and there were no recurrences of catamenial haemoptysis following the procedure. CONCLUSION: There is no guidance for the treatment of TE. Hormonal therapy can be considered to suppress the endometrial tissues. Considering the surgical options to treat TE, video assisted thoracic surgery was reported and which was found to be safer and less invasive than lobectomy. In general BAE is an alternative to surgery in the management haemoptysis caused by Tuberculosis and chest trauma. Even though, BAE has not been frequently used to treat TE we reported case of TE successfully treated with BAE. This suggests that BAE is an alternative treatment option for symptomatic TE.
Childbirth Experience Questionnaire (CEQ) in the Sri Lankan setting: translation, cultural adaptation and validation into the Sinhala language
(BioMed Central, 2020) Patabendige, M.; Palihawadana, T.S.; Herath, R.P.; Wijesinghe, P.S.
OBJECTIVE: To adapt the CEQ into Sri Lankan Sinhala cultural context and to determine the psychometric properties of CEQ. This would yield an opportunity to evaluate childbirth experience among Lankan population. RESULTS: Out of 390, 226 (57.9%) postnatal mothers completed the CEQ after 1 month postpartum. Face validity and content validity were demonstrated with all participants stating that CEQ was easy to understand and complete. For reliability, internal consistency was acceptable for the overall score (0.85) and for all four domains in CEQ (0.65, 0.80, 0.70, 0.83 for "own capacity", "professional support", "perceived safety" and "participation", respectively). A weighted kappa of 0.61-0.80 for all 22 items in CEQ demonstrated a good test-retest reliability. This Sri Lankan version showed fit statistics in line with standard recommendations in exploratory factor analysis. Women with spontaneous onset of labour (except for "professional support" in women with spontaneous onset of labour) and women with a normal birth showed significantly higher CEQ scores. However, oxytocin augmentation could not yield a difference in CEQ scores. KEYWORDS: Birth satisfaction; Childbirth experience questionnaire; Low-resource settings.
Choriocarcinoma of the ovary: a case report
(Sri Lanka College of Obstetricians and Gynaecologists, 2015) Ekanayake, C.D.; Wijesinghe, P.S.; Herath, R.P.; Puliyadda, T.M.N.K.; Hewavisenthi, S.J.de S.
Ovarian choriocarcinoma whether gestational or non-gestational, is an extremely rare malignant germ cell tumour. We report a young patient with an ovarian choriocarcinoma who was successfully treated with fertility sparing conservative surgery and adjuvant chemotherapy. Sri Lanka
Chronic nonpuerperal uterine inversion: laparotomy assisted vaginal hysterectomy
(Alkim Basin Yayin Ltd. Sti, 2011) Herath, R.P.; Hosni M.M.; Rashid, M.; Hassanaien, M.
Chronic nonpuerperal uterine inversion is an extremely rare clinical situation. We report a 36 year-old woman with chronic nonpuerperal uterine inversion due to a fundal leiomyoma. She was treated with laparotomy assisted vaginal hysterectomy. We emphasized the importance of abdominal access at the time of vaginal hysterectomy for complete inversion of uterus. After excluding possible bowel loops in the inverted uterus through abdominal incision, vaginal subtotal hysterectomy was performed followed by total hysterectomy. In addition to better surgical exposure, abdominal approach also helped management hemorrhage as in our case
Conservative management of Placenta Percreta: Three cases and a review of the literature regarding conservative management of Placenta Accreta Spectrum (PAS) Disorders.
(Hindawi Pub. Corp., 2020) Patabendige, M.; Sanjeewa, J.M.P.; Amarasekara, A.M.A.K.G.; Herath, R.P.
BACKGROUND: The incidence of placenta accreta spectrum (PAS) disorders has risen over the last decades, and there has been a gradual shift towards expectant management. Conservative management of PAS is known to reduce major obstetric haemorrhage and salvage hysterectomy. There is a lack of consensus on the follow-up of patients undergoing conservative approaches. Here, we describe the follow-up of three patients with placenta percreta who were conservatively managed and review the literature for the conservative management of PAS. Case Presentation. We have successfully managed three cases of placenta percreta expectantly using combined methods involving symphysial-fundal height, serum beta-HCG, and ultrasonographic volume of placental mass.CONCLUSIONS: Use of a combined approach with symphysial-fundal height, serum beta-HCG, and ultrasonographic volume of placental mass with colour Doppler may guide the surveillance of these conservatively managed cases. However, at least one magnetic resonance imaging three months postoperatively may predict a further risk of delayed haemorrhage.
Cost-effectiveness of three routes of hysterectomy: a multi-centre randomized controlled trial
(Sri Lanka College of Obstetricians & Gynaecologists, 2018) Ekanayake, C.D.; Pathmeswaran, A.; Kularatna, S.; Herath, R.P.; Wijesinghe, P.S.
BACKGROUND: Hysterectomy is the commonest major gynaecological surgical procedure. The aim of this study was to evaluate the cost-effectiveness of non-descent vaginal hysterectomy (NDVH) and total laparoscopic hysterectomy (TLH) compared to total abdominal hysterectomy (TAH). METHODS: A randomized controlled trial was conducted at the gynaecology unit, District General Hospital, Mannar and professorial gynaecology unit, North Colombo Teaching Hospital, Ragama. Study population (n=49 per arm) were women needing hysterectomy for non-malignant uterine causes. Exclusion criteria were uterus  14 weeks, previous pelvic surgery, those requiring incontinence/pelvic floor surgery, comorbidities which preclude laparoscopic surgery and women who were illiterate. Primary outcome was the time to recover following hysterectomy which was considered as the earliest time to resume activities done prior to surgery. A Kaplan-Meier survival analysis was done with pairwise comparison through log-rank test for the primary outcome. A micro-costing approach calculated utilization of hospital resources from the time of presentation up to six months after surgery. Incremental costeffectiveness ratios (ICER) were obtained by calculating the incremental costs divided by the incremental effects (time to recover) for the intervention groups (NDVH and TLH) over the standard care (TAH) group. RESULTS: The overall combined results from both centres did not show a significant difference in time to recover (median, 95% confidence interval) between TLH [30 days (29.0-31.0)], NDVH [32 days, (28.3-35.7)] and TAH [35 days (32.0-38.0)] (Kruskal-Wallis test, p=0.373). There was a significant difference in direct cost (median, inter quartile range) between TAH [Rs.41943, (38256-44476)] versus TLH [50608 (46670-54859)], Mann-Whitney U test, p<0.001, NDVH [Rs.40373 (3693244212) versus TLH, Mann-Whitney U test, p<0.001. There was no significant difference between TAH and NDVH, Mann-Whitney U test, p=0.076. ICERTLH-TAH was Rs. 1733/ day compared to TAH. ICERNDVH-TAH was not calculated as both the cost and effect were more favourable than TAH. ICERTLH-NDVH was Rs.3412/day compared to NDVH. CONCLUSIONS: There was no significant difference in time to recover between TLH, NDVH and TAH. The optimum approach to hysterectomy appears to be NDVH in terms of costeffectiveness due to its lower cost, a fact that was suggested from the interim analysis presented at SLCOG sessions in 2017.
Diagnostic and therapeutic dilemmas of cervical ectopic pregnancy
(Williams and Wilkins, 2014) Hosni, M.M.; Herath, R.P.; Mumtaz, R.
IMPORTANCE: Cervical pregnancy is a rare variety of ectopic pregnancy. The etiology is obscure. Its diagnosis may be difficult, and its management has enormously changed during the last 10 years. Unfortunately, the most effective, fertility-sparing treatment is still unclear until now. OBJECTIVES: The aim of this study was to explore the safety and efficacy of different treatment modalities of cervical pregnancy. Evidence Acquisition: A comprehensive systematic review of the literature was performed using the electronic databases MEDLINE and PubMed, using key words cervical, ectopic, and pregnancy, between January 2005 and June 2013. We included all case reports and case series reporting on cervical ectopic pregnancy. RESULTS: A total of 252 cases of cervical ectopic pregnancy were analyzed. Eighty-eight cases (34.9%) had medical treatment, 69 cases (27.5%) had surgical treatment, and 95 cases (37.6%) had combined medical and surgical treatment. Various conservative treatment regimens have been introduced to preserve fertility in young women, with methotrexate being one of the most widely used and effective drugs. CONCLUSIONS and Relevance: A high index of suspicion, combined with meticulous review of clinical and radiological findings, is essential to make an accurate diagnosis of cervical pregnancy. The success of conservative treatment depends mainly on early diagnosis. Such cases would be best managed at specialist tertiary referral centers and preferably, where available, Early Pregnancy Assessment Units, whether medical, surgical, or combined treatment modalities were attempted. Target Audience: Obstetricians, gynecologists, family physicians Learning Objectives: After participating in this activity, physicians should be better able to identify the most likely predisposing factors for cervical ectopic pregnancy, appraise different modalities of treatment, and apply the selection criteria for conservative management of cervical ectopic pregnancy. © 2014 by Lippincott Williams & Wilkins.
How can we reduce negative laparoscopies for pelvic pain?
(Informa Healthcare, 2011) Singh, N.; Rashid, M.; Herath, R.P.
Chronic pelvic pain is a common condition and the RCOG guideline provides an evidence-based framework for the initial assessment. This study investigated the adequacy and relevance of the initial assessment in patients who underwent elective laparoscopic procedure for pelvic pain. History-taking was found to be deficient and was unable to identify factors which may be related to the cause or perception of the pain. Only a small percentage benefitted from a therapeutic trial of hormonal and non-hormonal agents and referral to other specialities. Ultrasound and bimanual examination were both found to be of little value. Laparoscopy assisted in diagnosis in 45% of patients. A structured initial assessment and targeted selection of patients for laparoscopy would reduce the number of patients with normal findings and thus, it would reduce the number of women who suffer pain and isolation after a negative laparoscopy.
Hyperemesis gravidarum and fetal gender: a retrospective study
(Informa Healthcare, 2012) Rashid, M.; Rashid, M.H.; Malik, F.; Herath, R.P.
This retrospective study of 9,980 women who delivered at the James Paget Hospital, Norfolk, UK, over 5 years, aimed to primarily determine whether the incidence of hyperemesis gravidarum (HG) is higher in the presence of a female fetus. The results showed that more women with HG had a femalefetus compared with women without HG. Also found was that heavy ketonuria was more prevalent in women with a female fetus compared with women with a male fetus, and the mean number of admissions per woman was also higher in women with a female fetus compared with women with a male fetus. It can be concluded that women presenting with HG are more likely to have a female fetus and that women with HG and a female fetustend to a higher level of ketonuria and an increased number of hospital admissions.
Hyperglycaemia in pregnancy and anthropometric parameters in the offspring at 10 Years: A community-based retrospective cohort study in Sri Lanka
(Hindawi Publishing Corporation., 2020) Herath, H.P.; Herath, R.P.; Wickremasinghe, R.
BACKGROUND: Studies of developmental origins of health and disease have highlighted the possible role of intrauterine hyperglycaemia, increasing the future risk of obesity, diabetes, and cardiovascular diseases in the offspring. There is limited evidence from South Asian populations for risk estimates for childhood obesity that are attributable to maternal diabetes in utero. OBJECTIVE: The aim of this study was to determine the association between hyperglycaemia in pregnancy (HIP) and anthropometric parameters in the offspring at 10-11 years of age. METHODS: A community-based retrospective cohort study was conducted in Colombo district, Sri Lanka. In the first stage, children born in 2005 were identified, and the availability of antenatal records was assessed. In the second stage, the exposure status of participants was ascertained based on antenatal records and predefined criteria. In the third stage, height, weight, waist circumference, and triceps skinfold thickness (TSFT) of eligible participants were measured to ascertain the outcome status. Background characteristics were collected by interviewing mothers. A 24-hour dietary recall and a 3-day diet diary were recorded. RESULTS: 159 children of mothers with HIP (exposed) and 253 children of mothers with no HIP (nonexposed) participated. Mean ages (SD) of exposed and unexposed groups were 10.9 (0.3) and 10.8 (0.3) years, respectively. The median BMI (17.6 vs 16.1, p < 0.001), waist circumference (63 cm vs 59.3 cm, p < 0.001), and triceps skinfold thickness (13.7 mm vs 11.2 mm, p < 0.001) were significantly higher in the exposed group. Offspring of women with HIP were more likely to be overweight (aOR = 2.6, 95% CI 1.4-4.9) and have abdominal obesity (aOR = 2.7, 95% CI 1.1-6.5) and high TSFT (aOR = 2.2, 95% CI 1.06-4.7) at 10-11 years than children who were not exposed after adjusting for maternal BMI, maternal age at delivery, and birth order. CONCLUSIONS: Intrauterine exposure to HIP is a significant determinant of overweight, high TSFT, and abdominal obesity in the offspring.
Improvements of post caesarean section pain management following the introduction of a new pain management protocol
(Sri Lanka college of Obstetricians & Gynaecologists, 2017) Patabendige, M.; Herath, R.P.
OBJECTIVE :To evaluate improvements in post-caesarean section (CS) pain management in University Obstetrics Unit, Ragama, Sri Lanka following the introduction of a protocol for post-CS pain management. METHODS: A complete audit cycle was conducted in University Obstetrics Unit, Ragama, Sri Lanka. Initially a prospective audit was conducted among 126 consecutive CS during July and August, 2016. Basic demographic data and details regarding post-CS analgesia during the first 24 hours were collected. Re-auditing was done four months after the introduction of the protocol. In the re-auditing, 150 post-CS mother were conveniently selected over a period of three months and a coloured visual analogue scale (VAS) was used to assess the level of pain in the re-audit. RESULTS: There were no statistically significant difference between demographic details before and after the protocol. Before introduction of the protocol, use of diclofenac sodium rectal suppositories were the commonest analgesic type (42.9%) used. Only 6 (4.8%) out of 126 patients had properly documented pain management plan in the operative notes. None of the analgesics were prescribed for 6 (4.8%) patients. Out of total 126, only 6 (4.8%) subjects had a proper drug chart maintenance with regular analgesics. Forty two (33.3%) women were was not on any analgesics within the first 24 hours. After introduction of the protocol, regular analgesic dosing were given to 140 (93.3%) women with satisfactory drug chart maintenance in 140 (93.3%) cases. Out of 150, 140 (93.3%) patients received analgesia with at least a single method. Mean VAS score was 3.5 (SD 2.0) after first 24 hours. Diclofenac sodium suppository (86.7%) is the commenst first line medication. There was statistically significant difference (P < 0.05) in provision of pain relief after introduction of the protocol. CONCLUSION: There was a significant improvement in post-CS pain management after introduction of a new post-CS pain management protocol.
Laparoscopic management of genital prolapse
(Springer International, 2011) Mahran, M.A.; Herath, R.P.; Sayed, A.T.; Oligbo, N.
INTRODUCTION: Genital prolapse is one of the most common indications for gynaecological surgery. Surgery is performed traditionally via abdominal, vaginal and laparoscopic approaches. METHODS: A MEDLINE computer search was performed to explore the recent evidence behind laparoscopic surgery for female pelvic organ prolapse. RESULTS: Advances in minimal access surgery have led to an increase in adoption of laparoscopic techniques. Current evidence supports the use of laparoscopy for sacrocolpopexy and colposuspension as an alternative to open surgery. However, the introduction of less invasive midurethral sling procedures for stress incontinence has reserved laparoscopic colposuspension for special indications. The scientific evidence regarding uterosacral suspension procedures and paravaginal and vaginal prolapse repairs are sparse. CONCLUSION: The current evidence supports the outcome of laparoscopic sacrocolpopexy as an alternative to open surgery. Further studies are required on the long-term efficiency in laparoscopic paravaginal repair and vaginal wall prolapse.
Management of morbidly adherent placenta
(Sri Lanka College of Obstetricians and Gynaecologists, 2011) Herath, R.P.; Wijesinghe, P.S.
Morbidly adherent placenta is a rare complication of human placentation that may threaten maternal life due to massive haemorrhage. Its incidence is increasing due to the rising caesarean section rates worldwide. A high degree of clinical suspicion coupled with ultrasonography, magnetic resonance imaging, and cystoscopy helps in antenatal diagnosis. Elective caesarean hysterectomy with a multidisciplinary approach is the conventional treatment for confirmed cases of morbidly adherent placenta. However more conservative fertility saving approaches are also used successfully.
Methylene Blue induced bluish discoloration mimicking cyanosis, at diagnostic laparoscopy
(International Publisher of Science, Technology and Medicine, 2014) Herath, R.P.; Warnakulasuriya, T.; de Silva, A.; Wijesinghe, P.S.
BACKGROUND: Methylene blue is commonly used to check patency of Fallopian tubes and tracking fistulae. Intraversation of methylene blue is a recognized complication of diagnostic laparoscopy and dye test. Although a case of cyanosis due to methaemoglobinaemia following methylene blue use is a known complication, cyanosis without methaemoglobinaemia is unknown. CASE PRESENTATION: A 31 year old healthy female, being investigated for primary subfertility for 3 years underwent a diagnostic laparoscopy for evaluation of her fallopian tubes under general anaesthesia. Methylene blue 20 ml was injected to see the patency of the tubes. The patient became centrally cyanosed soon after dye ingestion. Her oxygen saturation dropped to 10% whilst her partial pressure of oxygen remained normal. CONCLUSION: Bluish discoloration of the body can occur in the absence of methaemoglobinaemia in patients undergoing laparoscopy following dye ingestion for evaluation of fallopian tubes using methylene blue. Recognizing this complication will help in avoiding unnecessary intervention to the patient. CASE PRESENTATION: A 31 year old healthy female, being investigated for primary subfertility for 3 years underwent a diagnostic laparoscopy for evaluation of her fallopian tubes under general anaesthesia. Methylene blue 20 ml was injected to see the patency of the tubes. The patient became centrally cyanosed soon after dye ingestion. Her oxygen saturation dropped to 10% whilst her partial pressure of oxygen remained normal.
Non-alcoholic fatty liver disease and pregnancy complications among Sri Lankan women: A cross sectional analytical study.
(Public Library of Science, 2019) Herath, R.P.; Siriwardana, S.R.; Ekanayake, C.D.; Abeysekara, V.; Kodithuwakku, S.U.A.; Herath, H.P.
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is the commonest cause of liver disease worldwide and is the hepatic manifestation of metabolic syndrome. Effects of NAFLD on pregnancy is still unclear with few studies showing an association to gestational diabetes and pre-eclampsia. We aimed to describe the association between the NAFLD and pregnancy complications. This is the first study, to our knowledge, in a South Asian population. METHOD: A cross sectional analytical study was done in Teaching Hospital, Ragama, Sri Lanka. Women carrying a singleton pregnancy, admitted for delivery were assessed for NAFLD with liver ultrasound scan. Data were extracted from interviewer administered questionnaire and antenatal and inpatient records. Pregnancy complications and labour outcomes were compared between the women with NAFLD and women without NAFLD (non-NAFLD). RESULTS: Out of the 573 women who participated, 18.2% (n = 104) were found to have NAFLD. Out of them, 58 (55.8%), 32(30.8%), and 14(13.5%) had fatty liver grade 1,2 and 3 respectively. Women with NAFLD were 2 times more likely to develop gestational hypertension and pre-eclampsia compared to the women in the non-NAFLD group, after adjusting for BMI, age and Hyperglycaemia in pregnancy [Adjusted OR 2.09, (95% CI 1.07-4.10)]. There was no association between the grade of steatosis and a composite outcome of gestational hypertension and pre-eclampsia, within the NAFLD group. Composite outcome of gestational diabetes mellitus and diabetes in pregnancy diagnosed during pregnancy was a significant complication in the NAFLD group compared to non-NAFLD group in the bivariate analysis (27.2% vs 17.7%; p<0.05), but the significance disappeared after adjusting for confounders. The current study did not demonstrate a significant association between NAFLD with preterm labour, caesarean section rate, low birth weight, and Apgar score of the baby. CONCLUSION: Women with NAFLD had a 2-fold higher risk of developing gestational hypertension and pre-eclampsia during pregnancy compared to women without NAFLD, after controlling for other confounding variables.