Browsing by Author "Jayaratne, A."

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    The prevalence of upper respiratory symptoms in a cohort of adults presenting with symptoms of gastro-oesophageal reflux disease
    (Sri Lanka Medical Association, 2016) Amarasiri, D.L.; Pathmeswaran, A.; Dassanayake, A.S.; de Silva, A.P.; Adikari, M.D.B.; Sanjeewa, P.A.B.; Jayaratne, A.; de Silva, H.J.
    INTRODUCTION: Gastro-oesophageal reflux disease (GORD) is the pathological reflux of gastric contents into the oesophagus. The oesophagus and the upper respiratory tract have a common origin from the foregut. There is increasing evidence for multiple associations of GORD with the upper respiratory tract. OBJECTIVES: To study the presence of and association of upper respiratory symptoms (URS) with GORD. METHODS: Seventy adults scoring ≥12.5 on a previously validated GORD symptom score (GORD patients) and 70 healthy controls who had infrequent GORD symptoms or no upper gastro-intestinal complaints completed a pre-tested URS questionnaire on the frequency of 14 URS in 5 categories (laryngeal, nasal, pharyngeal, sinusal and aural). All GORD patients underwent upper gastro-intestinal endoscopy. The calculated URS score was correlated against the GORD symptom score and endoscopy findings. RESULTS: URS scores and individual symptom scores were higher in GORD patients compared to controls (mean ± SE, 4.7 ± 4.0; 1.9 ± 2.3). Individuals with higher GORD symptom scores reported more frequent URS. Pharyngeal symptoms had the highest correlation with the GORD symptom score (r=0.507, p<0.001). The presence of oeso-phagitis did not seem to influence the frequency of reporting URS. CONCLUSION: Upper respiratory symptoms are common in individuals with GORD symptoms though there appears to be no association with oesophageal mucosal damage.
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    Upper respiratory symptoms are common in a cohort of patients with symptomatic gastrooesophageal reflux disease (GORD) in Sri Lanka
    (Wiley Blackwell Scientific Publications, 2011) Amarasiri, D.L.; Adikari, D.; Sanjeewa, B.; Jayaratne, A.; Dassanayake, A.S.; de Silva, A.P.; de Silva, H.J.
    INTRODUCTION: There is increasing evidence for multiple associations between gastro-oesophageal reflux disease (GORD) and the upper respiratory tract. This study evaluated the presence of upper respiratory symptoms (URS) in a cohort of patients with GORD symptoms from Sri Lanka. METHOD: Seventy adults scoring ≥12.5 on a previously validated GORD symptom score (GORD patients) and 70 healthy controls who had infrequent or no GORD symptoms completed a pre-tested, valid URS questionnaire. They were questioned on frequency of 14 URS in 5 categories (laryngeal, nasal, pharyngeal, sinusal and aural). All GORD patients underwent gastroscopy. An URS score was calculated and correlated against the GORD symptom score and gastroscopy fi ndings. RESULTS : The GORD patients (median age (range) 36 (15–65); 38% males) and controls (median age (range) 38 (15–68); 38% males) were comparable. URS scores were higher in GORD patients (mean ± SE, 4.7 ± 4.0) compared to controls (mean ± SE, 1.9 ± 2.3), as were individual symptom scores. Individuals with higher GORD symptoms scores reported more frequent URS. Nasal symptoms had the highest correlation with the GORD symptom score (r = 0.410; P = 0.001). of the GORD patients, 42 had no evidence of oesophageal or gastric mucosal damage. 28 had evidence of refl ux oesophagitis. In them, the presence of oesophagitis did not seem to influence the frequency of reporting URS. CONCLUSION : URS are common in individuals with GORD symptoms though there appears to be no association with oesophageal mucosal damage