Browsing by Author "Jayasinghe, A."

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Book Review: The Blind Musician by Vladimir Korolenko
(University of Kelaniya, Sri Lanka, 2021) Jayasinghe, A.
Buffaloes in favour of culture-based fisheries in Sri Lanka
(NETWORK OF AQUACULTURE CENTERS, 2007) Amarasinghe, U.S.; Jayasinghe, A.
Evalution of thyroid autoimmunity during iodine prophylaxis: the Sri Lankan experience
(BioScientifica Ltd., 2003) Mazziotti, G.; Premawardena, L.D.K.E.; Parkes, A.B.; Adams, H.; Smyth, P.P.A.; Smith, D.F.; Kaluarachi, W.N.; Wijeratne, C.N.; Jayasinghe, A.; de Silva, D.G.H.; Lazarus, J.H.
OBJECTIVE: To study the evolution of thyroid autoimmunity, in relation to the change in goitre prevalence, during 3 Years of iodine prophylaxis in Sri Lanka. METHODS: Two groups of Sri Lankan schoolgirls between the ages of 10.8 and 17.5 Years were studied in 1998 (401 girls) and 2001 (282 girls). A prospective study was performed in 42 schoolgirls who were thyroid autoantibody (Ab)-positive (+ve) in 1998. Anthropometric measures, urinary iodine excretion (UIE), thyroid Volume, free thyroxine, free tri-iodothyronine, TSH, and thyroglobulin (Tg) and thyroid peroxidase (TPO) Ab were evaluated in all 683 girls. RESULTS: Goitre prevalence was significantly lower in 2001 compared with 1998 related to age (2.9% compared with 20.2%) and body surface area (11.6% compared with 40.8%), although UIE was unchanged. Prevalence of thyroid Ab in 2001 was also lower (23.4% compared with 49.9%); among those with the Ab, 34.8% had TgAb alone and 46.9% had a combination of TgAb+TPOAb, compared with 82.0% TgAb alone in 1998. In 2001, subclinical hypothyroidism was more frequent in Ab+ve (6.3%) than Ab-negative girls (1.0%). A cohort of 42 Ab+ve schoolgirls in 1998 (34 with TgAb alone, eight with TgAb+TPOAb) were evaluated again in 2001. Only 10 of them (23.8%) remained Ab+ve (mostly TPOAb+/-TgAb) in 2001. CONCLUSIONS: This study demonstrates that: (1) in 2001, goitre prevalence and thyroid autoimmunity rates were significantly lower than in 1998; (2) the pattern of thyroid Ab was different in the two surveys; (3) in 2001 alone, the occurrence of hypothyroidism was correlated with the presence of thyroid autoimmunity. These results indicate an evolution of thyroid autoimmune markers during the course of iodine prophylaxis, which has not been described before.
Increased prevalence on thyroglobulin antibodies in Sri Lankan school girls - is iodine the cause?
(BioScientifica Ltd., 2000) Premawardena, L.D.K.E.; Parkes, A.B.; Smyth, P.P.A.; Wijeratne, C.N.; Jayasinghe, A.; de Silva, D.G.H.; Lazarus, J.H.
OBJECTIVE: Iodine deficiency was the likely cause of a high prevalence of goitre previously in Sri Lankan schoolchildren. Salt iodination was made compulsory in 1993 but there has been no recent study, using modern techniques, of its benefits or harmful effects. METHODS: Three hundred and sixty-seven schoolgirls between the ages of 11 and 16 years had ultrasound thyroid volume, free thyroxine (T4), free tri-iodothyronine (T3), thyrotrophin (TSH), anti-thyroglobulin (TgAb) and thyroid peroxidase (TPOAb) antibodies, and urine iodine concentrations measured. RESULTS: Median ultrasound thyroid volume ranged from 4.8 ml (11-year-old girls) to 8.6 ml (16-year-old girls) with an age-related increase. Median urine iodine concentrations ranged from 105 to 152 microg/l. Free T4 and free T3 were normal in all, but TSH was elevated in four subjects (5. 53-41.29 mU/l). However, the prevalence of TgAb was markedly raised, ranging between 14.3% (11-year-old girls) and 69.7% (16-year-old girls) (P<0.03). In contrast, the prevalence of TPOAb was 10% or less in all age groups. CONCLUSIONS: Normal median thyroid volumes, iodine concentrations and thyroid function would indicate that iodine deficiency is not a major problem in this group. The high prevalence of TgAb, hitherto unreported, most likely reflects excessive iodination of Tg resulting in increased immunogenicity. There is an urgent need to continuously monitor the adequacy and risks of iodination in this population
Iodine prophylaxis, goitre and thyroid autoimmunity in Sri Lanka
(Sri Lanka Medical Association, 2005) Wijeyaratne, C.N.; Jayasinghe, A.; de Silva, D.G.H.; Parkes, A.B.; Lazarus, J.H.; Premawardena, L.D.K.E.
No Abstract Available
Saving Behavior of Estate Sector in Sri Lanka: with Special Reference to Nuwaraeliya District
(Faculty of Graduate Studies, University of Kelaniya, Sri Lanka, 2016) Jayasinghe, A.; Maduwansa, N.A.N.J.; Rathnayake, G.; Senevirathne, B.
Saving is an important macroeconomic variable to be studied under the purview of the economic arena on a household basis. In Sri Lanka, the income standard is most uncertain and leads to more consumption rather than saving which has been a cardinal problem. Estate sector is one of the most energetic sectors of the economy of Sri Lanka. It is centered to limited economic activities. This study mainly focuses on underlining the determinants and significant factors of saving behavior of estate sector in Sri Lanka. The special features of this sector: poverty, minimum educational qualification and unemployment. Lack of educational qualification and lower level of income are the results of these interested teachers. The required data were acquired through a structured questionnaire and sampling method was simple random sampling with a sample size of 300 in the Ambagamuwa region in Nuwaraeliya district. The determinants of saving are analyzed empirically by a linear regression method and hidden factors are underlined by factor analysis. The income level, the expenditure level of education, confidence and savings are taken as the criteria for drawing the sample. The study finds that most of the estate sector households (72%) have a low educational qualification status, which is resulting in less awareness of the majority towards the benefits of savings. However, factor analysis found four common factors, namely lack of education, unconfidence, financial difficulties and purpose which determine the household saving behavior. Furthermore, it revealed three variables, namely level of education, confidence and purpose were significantly influenced savings. An efficient wage acts policy should be implemented by the government as many of the estate people are the daily wage workers, empowering them in proper ways which can satisfy their consumption needs and then some portion of the income can be saved.
Sequential studies on thyroid antibodies during pregnancy
(Mary Ann Liebert Publishers, 2005) Smyth, P.P.; Wijeyaratne, C.N.; Kaluarachi, W.N.; Smith, D.F.; Premawardena, L.D.K.E.; Parkes, A.B.; Jayasinghe, A.; de Silva, D.G.H.; Lazarus, J.H.
Thyroid antibodies were measured sequentially in 25 pregnant women from a Sri Lankan population. A high prevalence of antithyroidantibodies, particularly antithyroglobulin antibodies (TgAb) had previously been demonstrated in female schoolchildren drawn from this population. In the present study TgAb were detected in 36.8% of nonpregnant controls while thyroid peroxidase antibody (TPOAb) positivity was present in 26.3%. The prevalence of both antibodies in the pregnancy study group showed a progressive decline compared to nonpregnant controls throughout gestation becoming undetectable in the third trimester. The results are consistent with an immunosuppressive effect of pregnancy in a population in whom high thyroid autoantibody titers may have resulted from a recent salt iodization program.
A study of the spatial form of river base settlements at “Gurugoda Oya” valley
(Faculty of Social Sciences, University of Kelaniya, 2009) Fernando, K.D.; Abenayake, C.; Jayasinghe, A.
Thyroglobulin epitope recognition in post iodine supplemented Sri Lanka population
(Blackwell Scientific Publications, 2003) Okosime, O.E.; Premawardena, L.D.K.E.; Jayasinghe, A.; de Silva, D.G.H.; Smyth, P.P.A.; Parkes, A.B.; Lejeune, P.J.; Ruf, J.; Lazarus, J.H.
OBJECTIVE: We previously reported a high prevalence of raised thyroglobulin autoantibodies (TgAb) in apparently healthy Sri Lankan schoolgirls following salt iodination. To characterize these antibodies further we determined the epitopes on thyroglobulin (Tg) with which they react and compared these with serum obtained from both healthy subjects and established autoimmune thyroid disease (AITD) patients from the UK. To extend our study to a wider population within Sri Lanka, we in addition determined the epitopes recognized by a group of AITD patients selected from a thyroid clinic in Sri Lanka, as well as apparently healthy female Sri Lankan tea workers of distinct ethnicity from the schoolgirls and AITD patients. DESIGN: Sri Lankan schoolgirls (n = 282) and adult female tea estate workers (n = 208) were examined for thyroid autoimmune markers. Sera with high TgAb (> 98 kIU/l) were selected from these two groups (n = 36 and 45, respectively) to study epitope-binding patterns. We also examined the sera from 16 AITD patients attending a thyroid clinic in Colombo, 16 patients with AITD from the thyroid clinic at the University Hospital of Wales and 16 sera from healthy control UK women with no evidence of thyroid disease. To determine the epitopes on Tg recognized by the subjects' TgAb, we employed a panel of Tg mouse monoclonal antibodies labelled with alkaline phosphatase in a competitive enzyme-linked immunosorbent assay reaction with the subjects' serum. RESULTS AND CONCLUSIONS: A majority of the Sri Lankan schoolgirls did not react with the immunodominant epitopes and did not differ significantly from healthy subjects from the UK in their Tg epitope recognition pattern. On the other hand, tea estate workers and Sri Lankan AITD patients recognized typical autoimmune thyroid disease epitopes and, in addition, recognized a separate cluster not previously associated with either the autoimmune state or the healthy state. The significance of this cluster requires further clarification
බර්නාඩාගේ සිපිරි ගෙය
(Faculty of Humanities, University of Kelaniya, Sri Lanka, 2015) Jayasinghe, A.
භාෂා පරිවර්තනයේ දී හමු වන සංස්කෘතික ගැටලු නිරාකරණය කරගන්න අයුරු (සිංහල හා දෙමල භාෂාවල සංස්කෘතික යෙදුම් ඇසුරින්)
(Faculty of Humanities, University of Kelaniya, Sri Lanka, 2014) Jayasinghe, A.