Browsing by Author "Jayaweera, J.A.A.S."

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Association of Hantavirus infections and Leptospirosis with the occurrence of Chronic Kidney Disease of Uncertain Etiology in the North Central Province of Sri Lanka: A prospective study with patients and healthy persons
(Frontiers Media SA, 2020) Sunil-Chandra, N.P.; Jayaweera, J.A.A.S.; Kumbukgolla, W.; Jayasundara, M.V.M.L.
ABSTRACT: Chronic Kidney disease of uncertain etiology (CKDu) has become a significant disease burden, affecting farming community of Sri Lanka and the exact etiology, which could be multifactorial, is not hitherto established. This study is aimed to determine the association of past hantavirus infection and leptospirosis with the occurrence of CKDu. A cohort (n = 179) of known CKDu patients living in high-CKDu prevalent areas of Anuradhapura district of Sri Lanka was compared with a group of 49 healthy, sex-matched younger blood relatives of CKDu patients (control-1) and another 48 healthy, age, and sex-matched individuals living in low-CKDu prevalent area (control-2) of the same district where same life style and climate conditions prevail. Fifty out of 179 (27.9%) CKDu patients, 16/49 (32.7%) of control-1 and 7/48 (14.6%) of control-2 were found positive for IgG antibodies to Puumala, Hantaan or both strains of hantaviruses. Hantaan strain specificity was found to be predominant in all study groups. Hantavirus IgG sero-prevalence of healthy individuals living in low-CKDu prevalent area was significantly lower compared to CKDu patients and healthy younger blood relatives living in high-CKDu prevalent areas (p = 0.03). Past hantavirus infection possesses a significant risk for the occurrence of CKDu (OR = 4.5; 95% CI-3.1-5.4, p = 0.02). In contrast, IgG seroprevalence to hantaviruses was not significantly different in CKDu patients and healthy younger blood relatives living in high-CKDu prevalent areas indicating past hantavirus infection has no association with the occurrence of CKDu or possibly, younger relatives may develop CKDu in subsequent years. Seroprevalence to leptospirosis showed no significant difference between CKDu patients and healthy controls. KEYWORDS: CKDu; chronic kidney disease; hantaviruses; leptospira; sero-prevalence. Erratum in: Front Cell Infect Microbiol. 2020;10:631515
Corrigendum: Association of Hantavirus infections and Leptospirosis with the occurrence of Chronic Kidney Disease of Uncertain Etiology in the North Central Province of Sri Lanka: A Prospective study with patients and healthy persons
(Frontiers Media SA, 2020) Sunil-Chandra, N.P.; Jayaweera, J.A.A.S.; Kumbukgolla, W.; Jayasundara, M.V.M.L.
[This corrects the article doi: 10.3389/fcimb.2020.556737]. Erratum for : Association of Hantavirus infections and Leptospirosis with the occurrence of Chronic Kidney Disease of uncertain etiology in the North Central Province of Sri Lanka: A Prospective study with patients and healthy persons [Frontiers in Cellular and Infection Microbiology. 2020;10:556737].
Healing effects of Sri Lankan traditional and Ayurvedic medicine in shaft of humorous fractures with non-union state: a case report.
(Department of Shalya Shalakya,Gampaha Wickramarachchi Ayurveda Institute,University of Kelaniya,Sri Lanka, 2017) Attanayake, A.M.H.S.; De Silva, U.M.G.D.; Jayaweera, J.A.A.S.
In Ayurveda, Sushruta Samhita describes Bhagna Chikitsa (treatments for fractures). Sri Lanka has a well-established traditional orthopedic treatment system (Kedum Bindum Vedakama).Shaft of humerus fractures are common over middle one-third. It is common in adults as well as in children. A 14 year-old child was subjected to a compound fracture over shaft of humorous. Three months following allopathic treatment, he was presented to Ayurveda for further management. At the beginning, fracture was aligned and immobilized using “k” wire (mode of internal xation) over three weeks and it was removed. The patient presented with an external wound with wasting of forearm and restricted movements of elbow, wrist and ngers. Anteroposterior(AP) and lateral (L) views of the X-ray reports showed non-union of the bones. Total duration of the treatment was 6 months. Initially, all non-united bone fragments were immobilized for 6 months using bamboo splints. Prior to applying the two splints over lateral and medial sides of the arm, herbal oils of Seethodaka, Pinda, Narayana and herbal paste ofKatakala were applied. Subsequently, up to 6 months, motor, sensory function assessment and quality of life assessment with quality of life of the international osteoporosis foundation(QLIOF) were done following Ayurveda treatment. Initial power of wrist and ngers was grade 1and at the end of 6-month it improved to grade 5. The difference in the QLIOF scores was analyzed using Wilcoxon signed rank test. There was a signicant (p<0.05) difference between the pre-treatment (14) and post-treatment (59) QLIOF scores. The evidence of AP and L views of the X-ray showed complete heal of the fracture. A study with a larger population is proposed to assess the efcacy of the given Ayurveda treatment protocol.
Swine Flu research: A scientometric study of global perspectives
(12th Annual Research Symposium, University of Kelaniya, 2011) Balasubramani, R.; Jayaweera, J.A.A.S.; Siriwardna, A.S.; Kumbukgolla, W.W.; Bandara, A.B.P.