Browsing by Author "Lee, T. H."

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    Anammox bacteria in treating ammonium rich wastewater: Recent perspective and appraisal
    (Bioresource Technology, 2021) Weralupitiya, C.; Wanigatunge, R.; Joseph, S.; Athapattu, B. C.; Lee, T. H.; Kumar Biswas, J.; Ginige, M. P.; Shiung Lam, S.; Senthil Kumar, P.; Vithanage, M.
    The discovery of anammox process has provided eco-friendly and low-cost means of treating ammonia rich wastewater with remarkable efficiency. Furthermore, recent studies have shown that the possibility of operating the anammox process under low temperatures and high organic matter contents broadening the application of the anammox process. However, short doubling time and extensive levels of sensitivity towards nutrients and environmental alterations such as salinity and temperature are the limitations in practical applications of the anammox process. This review article provides the recent yet comprehensive viewpoint on anammox bacteria and the key perspectives in applying them as an efficient strategy for wastewater treatment.
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    Blood pressure variability and outcome in acute ischemic and hemorrhagic stroke: a post hoc analysis of the HeadPoST study.
    (Scientific & Medical, Macmillan Press, 2019) Minhas, J. S.; Wang, X.; Lavados, P.M.; Moullaali, T.J.; Arima, H.; Billot, L.; Hackett, M.L.; Olavarria, V.V.; Middleton, S.; Pontes-Neto, O.; de Silva, H.A.; Lee, T. H.; Pandian, J. D.; Mead, G. E.; Watkins, C.; Chalmers, J.; Anderson, C.S.; Robinson, T.G.; HeadPoST Investigators
    The Head Positioning in Acute Stroke Trial (HeadPoST) is a pragmatic, international, cluster crossover randomized trial of 11,093 patients with acute stroke assigned to a lying-flat (0°) or sitting-up (head elevated ≥30°) position. This post hoc analysis aimed to determine the association between blood pressure variability (BPV) and outcomes for patients from a wide range of international clinical settings and how the association was modified by randomized head position. BPV was defined according to the standard criteria, with the key parameter considered the coefficient of variation (CV) of systolic BP (SBP) over 24 h. Outcome was ordinal 90-day Modified Rankin Scale (mRS) score. The association was analyzed by ordinal, logistic regression, hierarchical, mixed models with fixed intervention (lying flat vs. sitting up), and fixed period, random cluster, and random cluster-period, effects. Nine thousand one hundred and fifty six (8324 acute ischemic stroke and 817 intracerebral hemorrhage; mean age 68.1 years; 39.2% women) were included in the analysis. CV of SBP had a significant linear association with unfavorable shift of mRS at 90 days (adjusted odds ratio 1.06, 95% confidence interval 1.02–1.11; P = 0.01). There was no heterogeneity of the association by randomized head positioning. In addition, CV of diastolic BP (DBP) (1.08, 1.03–1.12; P = 0.001) over 24 h post stroke was significantly associated with 3-month poor outcome. The association was more apparent in sitting-up position (1.12, 1.06–1.19) compared with lying-flat position (1.03, 0.98–1.09) (P interaction = 0.005). BPV was associated with adverse stroke outcome, and the magnitude of the association was greater with sitting-up head positioning in terms of DBP variability.