Browsing by Author "Malalavidhane, T.S."

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An Aqueous extract of the green leafy vegetables Ipomoea aquatica is as effective as the oral hypoglacaemic drug Tolbutamide in reducing the blood sugar levels of Wistar rats
(Wiley, 2001) Malalavidhane, T.S.; Wickremasinghe, S.M.D.N.; Jansz, E.R.
This study was undertaken to compare the oral hypoglycaemic activity of an aqueous extract of the green leafy vegetable Ipomoea aquatica (dose equivalent to 3.3 g starting material /kg body weight) with that of the known oral hypoglycaemic drug tolbutamide (15 mg/kg body weight) in glucosechallenged Wistar rats (3 g/kg body weight, administered 30 min after the administration of Ipomoea aquatica or tolbutamide). One and half hours after administration of glucose (equivalent to 2 h after administration of plant extract or tolbutamide), the mean blood glucose level of the Ipomoeaaquatica treated group was 47.5% lower than that of the control group treated with distilled water. The tolbutamide treated group showed a meanblood glucose level which was only 33.8% lower than that of the control group. However, statistical analysis indicated that the blood glucose levels of the Ipomoea aquatica treated group were not significantly different from that of the tolbutamide treated group. Our results show that the aqueousextract of Ipomoea aquatica is as effectve as tolbutamide in reducing the blood glucose levels of glucose-challenged Wistar rats.
The Oral hypoglacaemic activity of Ipomea aquatica
(Elsevier, 2000) Malalavidhane, T.S.; Wickremasinghe, S.M.D.N.; Jansz, E.R.
Ipomoea aquatica is a commonly consumed green leafy vegetable in Sri Lanka which is supposed to possess an insulin-like activity [Jayaweera, D.M.A., 1982. Medicinal Plants (Indigenous and Exotic) Used in Ceylon. Part 11. National Science Council, Colombo, Sri Lanka, pp. 99]. Only a little attention has been paid to the therapeutic use of this plant. We studied the oral hypoglycaemic activity of single and multiple doses of I. aquatica in healthy, male Wistar rats after a glucose challenge. There was a significant reduction in the serum glucose concentrations with both single (33%, P<0.0027) and multiple (25%, P<0.02) doses. The optimum dose was 3.4 g/kg while the optimum activity was given 2 h after the administration of the extract. The present study indicates that a boiled, whole extract of I. aquatica exerts an oral hypoglycaemic effect in healthy, male, Wistar rats after a glucose challenge.
Oral hypoglygaemic activity of Ipomea aquatica in streptozotocin induced diabetic wistar rats and type II diabetics
(Wiley, 2003) Malalavidhane, T.S.; Wickremasinghe, S.M.D.N.; Perera, M.S.A.; Jansz, E.R.
Ipomoea aquatica Forsk is a common green leafy vegetable consumed in many parts of the world. The present study was designed to investigate theoral hypoglycaemic activity of Ipomea aquatica in streptozotocin induced diabetic Wistar rats, and Type II diabetic patients. Experimental diabetes was induced with streptozotocin in Wistar rats. The rats were then divided into test and control groups. In addition to the standard feed given to both groups the test was fed with the shredded leaves of Ipomoea aquatica (3.4 g/kg) for one week. Type II diabetic patients were subjected to a glucose challenge before and after a single dose of blended I. aquatica. Patients acted as their own controls. The results revealed that consumption of the shredded, fresh, edible portion of I. aquatica for one week, effectively reduced the fasting blood sugar level of streptozotocin-induced diabetic rats (p = 0.01). When subjected to a glucose challenge, the Type II diabetic subjects showed a significant reduction (p = 0.001) in the serum glucose concentration 2 h after the glucose load. However, it was not significantly reduced at 1 h (p < 0.09) post glucose load. There was a 29.4% decrease in the serum glucose concentration of the diabetic patients when treated with the plant extract.
A preliminary study on the effect of a single dose of Ipomoea aquatica (Convolvuiaceae) on intestinal glucose absorption of healthy, male, Wistar rats
(University of Kelaniya, Sri Lanka, 2003) Malalavidhane, T.S.; Wickramasinghe, S.M.D.N.; Jansz, E.R.
Abstract available