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Browsing by Author "O'Hehir, R."

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    The Effect of intestinal nematode infections on atopic diseases in children
    (Allergy and Immunology Society of Sri Lanka, 2009) Amarasekera, N.D.D.M.; Gunawardena, N.K.; de Silva, N.R.; Douglas, J.; O'Hehir, R.; Weerasinghe, A.
    BACKGROUND : The effect of helminth infections on atopic diseases and allergic sensitization is controversial. Little is known about the effect of infection on atopic diseases in children living in areas where both intestinal nematodes and Toxocara infections are prevalent. OBJECTIVE : To examine the association between atopic diseases and helminth infection among children exposed to both intestinal nematodes and Toxocara. METHODS: Children attending grade 5 (age group 9-11 years) in 17 schools in the Western Province of Sri Lanka were recruited. The association of atopic diseases (asthma, rhinitis, eczema) with active intestinal nematode infections (excreting eggs in faeces) and with exposure to Toxocara (specific IgG antibodies in serum) was investigated. A child was deemed sensitized if positive for at least one of the allergens tested (Dermatophagoides pteronyssinus, Blomia tropicalis, cockroach, cat epithelium, grass pollen), based on specific IgE levels in serum. RESULTS: A total of 640 children participated in the study; serum analysis was done in 203. Active intestinal nematode infection appeared to reduce the risk of atopic diseases (OR 0.47, P=0.016) whereas Toxocara exposure did not (OR 0.85 P=0.602). When specific IgE levels against Blomia tropicalis, the most common allergen in the study group (67.5%), were expressed as percentages of the total IgE levels for each child, infected children had significantly lower levels compared to uninfected children (P=0.001). CONCLUSIONS : Intestinal nematode infections seem to protect against atopic diseases in children in Sri Lanka. Polyclonal IgE synthesis may be involved in this protection.

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