Browsing by Author "Perera, P.P.R."

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Association between homocysteine, vitamin B12, folate, MTHFR polymorphisms and ischaemic heart disease
(Sri Lanka Medical Association, 2010) Perera, P.P.R.; Chandrasena, L.G.; Indrakumar, J.; Peiris, H.
OBJECTIVES: The present study investigated the association between homocysteine and ischaemic heart disease (IHD) and the factors influencing homocysteine levels. METHODS: A case control study involving 221 patients with IHD and 221 age and sex matched controls admitted to Colombo South Teaching Hospital and an analytical study involving 79 patients awaiting coronary artery bypass grafting at Nawaloka Hospitals PLC were done. RESULTS: Hyperhomocysteinaemia was a significant predictor of IHD after controlling for hypertension and hypercholesteroleamia (adjusted odds ratio 2.38). Hyperhomocysteinaemia was a significant predictor of IHD in the young but not in the elderly. Among persons below 50 years, persons with hyperhomocysteinaemia were 4.5 times more likely to develop IHD as compared to those with normohomocysteinaemia. Vitamin B^ and folate levels showed a negative correlation with serum homocysteine concentrations. The homocysteine concentration did not differ significantly with the genotypes of Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms. CONCLUSIONS: People with hyperhomocysteinaemia have a 2-3 fold increase in risk of developing IHD. Hyperhomocysteinaemia is a predictor of IHD in the young but not in the elderly. A decrease in either vitamin B12 or folate concentrations in serum is associated with higher homocysteine concentrations whereas MTHFR A1298C and C677T gene mutations do not have an effect on the homocysteine concentrations.
Glutathione peroxidase and severity of ischaemic heart disease in a cohort of Sri Lankan patients
(Sri Lanka Medical Association, 2010) Perera, P.P.R.; Chandrasena, L.G.; Indrakumar, J.; Peiris, H.
OBJECTIVES: To study the association between glutathione peroxidase (GPx) levels in relation to severity and extent of cardiac ischemia and age in a cohort of Sri Lankans. METHODS: Seventy nine patients with ischaemic heart disease (IHD) awaiting coronary artery bypass grafting (CABG) were recruited to the study. GPx was measured before CABG. The severity and extent of myocardial ischemia were measured by the vessel, stenosis and extent scores by perusing the coronary angiograms. RESULTS: The mean GPx concentration of the study sample was 120.44 units GPx/mg Hb which is below the normal value of 275 units GPx/mg Hb. The mean vessel, stenosis and extent scores of the study sample were 2.04 (out of a possible 3) 9.86 (out of a maximum of 32) and 46.42% respectively. The GPx levels showed a significant inverse correlation with the vessel, stenosis and extent scores (p < 0.01), No significant correlation was observed between the GPx levels and age in the study population. CONCLUSIONS: GPx may be a predictor of severity and extent of ischaemia in ischemic heart disease patients. GPx levels did not change with the age.
Knowledge and practices regarding primary prevention of cardiovascular diseases among adults aged 18-30 years in Colombo District, Sri Lanka
(Faculty of Medicine, University of Kelaniya, Sri Lanka, 2021) Senatilleke, N.H.N.; Ramanayaka, R.A.P.D.; Premathilake, K.D.H.D.; Dissanayake, D.M.D.H.U.; Fernando, W.K.M.; Senaratne, B.C.V.; Perera, P.P.R.
Introduction: Research on knowledge and practices regarding primary prevention of CVD among adults aged 18-30 years are lacking in Sri Lanka. Objectives: To describe knowledge and practices on diet and lifestyle in preventing cardiovascular diseases and its associated factors among adults aged 18-30 years in the Colombo District. Methods: A descriptive cross-sectional study was conducted recruiting volunteers via a self-administered online Google form. Results: Sample size was 383 participants, ranging from age 18 to 30 years. Majority of the participants (63.2%) had a good overall knowledge (mean score - 73.24% ±SD-18.5). Majority were unaware of the value of fruits and vegetables in the diet (n=203, 53.0%). 53.3% had an average level of overall practices in diet and lifestyle. Inadequate physical activity levels were observed in 60.1% of participants. There was a significant association between good level of practices with male gender (p=0.016) and being undergraduate (p=0.025). The tendency to engage in physical activity was significantly associated with age (p=0.02), being male (p=0.004), and being an undergraduate (p=0.022). Smoking was significantly associated with male gender (p<0.01), age (p=0.046) and lower monthly income (p=0.047). Consuming alcohol had a significant association with male gender (p<0.01) and highest educational qualification (p<0.01). There was a significant association between good level of knowledge and good level of practice (p=0.042). Conclusions: Even though majority of the participants had a good level of knowledge majority had an average level of practice in diet and lifestyle in preventing CVD.