Browsing by Author "Smyth, P.P."

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    Sequential studies on thyroid antibodies during pregnancy
    (Mary Ann Liebert Publishers, 2005) Smyth, P.P.; Wijeyaratne, C.N.; Kaluarachi, W.N.; Smith, D.F.; Premawardena, L.D.K.E.; Parkes, A.B.; Jayasinghe, A.; de Silva, D.G.H.; Lazarus, J.H.
    Thyroid antibodies were measured sequentially in 25 pregnant women from a Sri Lankan population. A high prevalence of antithyroidantibodies, particularly antithyroglobulin antibodies (TgAb) had previously been demonstrated in female schoolchildren drawn from this population. In the present study TgAb were detected in 36.8% of nonpregnant controls while thyroid peroxidase antibody (TPOAb) positivity was present in 26.3%. The prevalence of both antibodies in the pregnancy study group showed a progressive decline compared to nonpregnant controls throughout gestation becoming undetectable in the third trimester. The results are consistent with an immunosuppressive effect of pregnancy in a population in whom high thyroid autoantibody titers may have resulted from a recent salt iodization program.