Browsing by Author "Suresh, T.S."

Now showing 1 - 3 of 3

Could food be our medicine?
(Faculty of Medicine, University of Kelaniya, 2015) Suresh, T.S.
Introduction: Non communicable diseases are becoming an alarming threat to humans at present. The high prevalence of diabetes mellitus in Asia is a challenge to health care professionals. With numerous limitations attributed to existing allopathic drugs, more attention is being paid to introduce functional foods which exert beneficial health effects. A few studies were conducted with the aim of identifying suitable functional foods that can be popularized among the community. The hypoglycaemic effects of the hot water extract of dried flowers of Aegle marmelos and the culinary mushrooms; American oyster (Pleurotus ostreatus) and abalone (P. cystidiosus) in Type II diabetic patients on diet control were studied. Methodology: The study was conducted at the Faculty of Medical Sciences, University of Sri Jayewardenepura, Sri Lanka. Following ethical clearance, ninety, volunteer patients were recruited (n=30/group). A glucose challenge test was performed on Day 1 and the concentration of serum glucose and insulin were measured. Same procedure was repeated on a subsequent day where patients received a single dose of respective extracts ½h prior to glucose and serum glucose and insulin were measured. The extracts were given daily for 2 weeks and liver enzymes and creatinine levels were measured. Results: Consumption of A. marmelos, P. autreatus and P. cystidiosus extracts signifcantly reduced (p<0.05) the concentrations of fasting as well as 2h serum glucose in the teste subjects. The serum insulin concnetrations were signifcantly increased (p<0.05) following treatment. The serum concentrations of liver enzymes and creatinine were not affected. Discussion: The drink of A. marmelos is a very popular beverage in Sri Lanka. The findings validadte its use as a functional food which can be safely consumed daily. Similarly the study confirms that the American oyster and abalone mushrooms which are consumed fresh as well as dried, are capable of improving glucose tolerance in diabetic patients.
Evaluation of In vivo for anti-histamine activity of Munronia pinnata
(Gampaha Wickramarachchi Ayurveda Institute, University of Kelaniya, 2014) Hapuarachchi, S.D.; Suresh, T.S.; Senarath, W.T.P.S.K.; Haunnetthi, S.M.
A study on safety evaluation of “Rasnasapthakaya” decoction in healthy volunteers
(Faculty of Medicine, University of Kelaniya, Sri Lanka, 2016) Sanjeev, R.; Suresh, T.S.; Dahanayake, J.M.
BACKGROUND: Rasnasapthakaya (RS) is a decoction of potent anti - inflammatory herbal preparation which is used to treat chronic inflammatory joint disorders in ayurvedha medicine. The constituents of RS decoction are: Alpinia calcarata, Tinospora cordifolia, Cassia fistula, Boerhavia diffusa, Cedrus deodara, Ricinus communis and Tribulus testretris. Several scientific studies of RS decoction in Wistar rats revealed that the decoction itself has potent anti-inflammatory, analgesic, anti-oxidant and anti-histamine properties. OBJECTIVES: To determine the safety of RS in healthy volunteers. METHODS: Thirty healthy volunteers aged 18 – 60 of either sex were recruited by open advertisement. Every day, freshly prepared RS was distributed in dark bottles (240ml/day) for 14 days. The participants were advised to take 120 ml (½ patha) in the morning and night after meals. Blood was drawn on day 0, 8 and 15 for evaluation of selected liver and kidney function tests. (Serum ALT, AST, ALP, γGT , Creatinine and Urea). RESULTS: According to the findings of the study, there were no statistically significant (p>0.05) changes observed in day 8 and 15 when compared to the base line values. CONCLUSIONS: RS does not cause any significant adverse effects with the therapeutic dose used in Ayurvedha.