Browsing by Author "Wanigasekara, D.N."

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    Determination of antimicrobial efficacv of four Ayurveda Local Applications (Pratisarana Yoga) in the management of Periodontal Disease
    (International Journal of Applied Science and Research, Volume 2, Issue 3, 2019) Peiris, K.P.P.; Wanigasekara, D.N.; Sudesh, A.D.H.; Katunatathne, E.D.C.
    This study evaluates the antimicrobial activity of four Ayurvedic formulations namely Kushtadi Ehurna, Swethamaniana Churna, Karanladi Churna and Dasana Sanskara Churna that are used to treat periodontal diseases as local applications. The objectives are to find out the presence or absence of in-vitro antimicrobial efficacy of these four drugs and to evaluate the antimicrobial efficacy of them using agar well diffusion method. The organisms used for the study are Staphylococcus aureus (ATCC 29213), Metlucillin resistant Staphylococcus aureus (ATCC 25923) and clinically isolated Candida albicans. The results of the in-vitro antimicrobial efficacy study reveals that Swethamanjana Chuma possesses antimicrobial action against all three tested microorganisms. Kushtadi Churna is cffcctivc against S. aureus (ATCC 29213) and MRSA (ATCC 25923) and it is unable ro affect rhe growth of C. albicans. Karaniadi Churna and Dasana Sanskara Chuma are effecnve against S. aureus (ATCC 29213) and C. albicans and not effective against MRSA(ATCC 25923). Fluconazole and Amoxicillin are used as positive controls for the yeast and two bacteria respectively.
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    In-vitro evaluation of antimicrobial efficacy of the indigenous formulation, Karna Bindu against common pathogens causing otitis infections.
    (International Journal of Scientific Research and Innovative Technology, Volume 6, Issue 7, 2019) peiris, K.P.P.; Wanigasekara, D.N.; Sudesh, A.D.H.; Karunarathne, E.D.C.
    This study investigates the efficacy of the formulation named "Karna Bindlö' which has been used in indigenous medicinal practices to treat ear infections such as otitis media and otitis externa. The objectives are to determine the antimicrobial efficacy of Karna Bindu against Aspergillus niger,Candida alhicans and Pseudomonas aeruginosa and to compare the efficacy of the indigenous formulation with the conventional antibiotics that are used for the test organisms. By using the agar well diffusion method, the test organisms were cultivated and the relevant antibiotics were used as positive controls while sterile distilled water served as the negative control. The antimicrobial assay revealed that Karna Bindu is effective against all three selected microorganisms. The Minimum Inhibitory Concentrations (MIC) of the formulation for C. albicans and aeruginosa were recorded as 500 gL/mL, and 750 gL/mL accordingly.