Browsing by Author "Zhang, H."

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A global survey on the use of the international classification of diseases codes for metabolic dysfunction-associated fatty liver disease
(Springer, 2024) Zhang, H.; Targher, G.; Byrne, C.D.; Kim, S.U.; Wong, V.W.; Valenti, L.; Glickman, M.; Ponce, J.; Mantzoros, C.S.; Crespo, J.; Gronbaek, H.; Yang, W.; Eslam, M.; Wong, R.J.; Machado, M.V.; Yu, M.; Ghanem, O.M.; Okanoue, T.; Liu, J.; Lee, Y.; Xu, X.; Pan, Q.; Sui, M.; Lonardo, A.; Yilmaz, Y.; Zhu, L.; Moreno, C.; Miele, L.; Lupsor-Platon, M.; Zhao, L.; LaMasters, T.L.; Gish, R.G.; Zhang, H.; Nedelcu, M.; Chan, W.K.; Xia, M.; Bril, F.; Shi, J.; Datz, C.; Romeo, S.; Sun, J.; Liu, D.; Sookoian, S.; Mao, Y.; Méndez-Sánchez, N.; Wang, X.; Pyrsopoulos, N.T.; Fan, J.; Fouad, Y.; Sun, D.; Giannini, C.; Chai, J.; Xia, Z.; Jun, D.W.; Li, G.; Treeprasertsuk, S.; Li, Y.; Cheung, T.T.; Zhang, F.; Goh, G.B.; Furuhashi, M.; Seto, W.; Huang, H.; Sessa, A.D.; Li, Q.; Cholongitas, E.; Zhang, L.; Silveira, T.R.; Sebastiani, G.; Adams, L.A.; Chen, W.; Qi, X.; Rankovic, I.; Ledinghen, V.D.; Lv, W.; Hamaguchi, M.; Kassir, R.; Müller-Wieland, D.; Romero-Gomez, M.; Xu, Y.; Xu, Y.; Chen, S.; Kermansaravi, M.; Kuchay, M.S.; Lefere, S.; Parmar, C.; Lip, G.Y.H.; Liu, C.; Åberg, F.; Lau, G.; George, J.; Sarin, S.K.; Zhou, J.; Zheng, M.; Niriella, M.A. (MAFLD ICD-11 coding collaborators)
BACKGROUND With the implementation of the 11th edition of the International Classification of Diseases (ICD-11) and the publication of the metabolic dysfunction-associated fatty liver disease (MAFLD) nomenclature in 2020, it is important to establish consensus for the coding of MAFLD in ICD-11. This will inform subsequent revisions of ICD-11.METHODS Using the Qualtrics XM and WJX platforms, questionnaires were sent online to MAFLD-ICD-11 coding collaborators, authors of papers, and relevant association members.RESULTS A total of 890 international experts in various fields from 61 countries responded to the survey. We also achieved full coverage of provincial-level administrative regions in China. 77.1% of respondents agreed that MAFLD should be represented in ICD-11 by updating NAFLD, with no significant regional differences (77.3% in Asia and 76.6% in non-Asia, p = 0.819). Over 80% of respondents agreed or somewhat agreed with the need to assign specific codes for progressive stages of MAFLD (i.e. steatohepatitis) (92.2%), MAFLD combined with comorbidities (84.1%), or MAFLD subtypes (i.e., lean, overweight/obese, and diabetic) (86.1%).CONCLUSIONS This global survey by a collaborative panel of clinical, coding, health management and policy experts, indicates agreement that MAFLD should be coded in ICD-11. The data serves as a foundation for corresponding adjustments in the ICD-11 revision.
Investigating the benefits of molecular profiling of advanced non-small cell lung cancer tumors to guide treatments
(Impact Journals, 2018) Alifrangis, C.; Carter, P.; Cereser, B.; Chandrasinghe, P.; Belluz, L.D.B.; Lim, E.; Moderau, N.; Poyia, F.; Tabassum, N.; Zhang, H.; Krell, J.; Stebbing, J.
In this study we utilized data on patient responses to guided treatments, and we evaluated their benefit for a non-small cell lung cancer cohort. The recommended therapies used were predicted using tumor molecular profiles that involved a range of biomarkers but primarily used immunohistochemistry markers. A dataset describing 91 lung non-small cell lung cancer patients was retrospectively split into two. The first group's drugs were consistent with a treatment plan whereby all drugs received agreed with their tumor's molecular profile. The second group each received one or more drug that was expected to lack benefit. We found that there was no significant difference in overall survival or mortality between the two groups. Patients whose treatments were predicted to be of benefit survived for an average of 402 days, compared to 382 days for those that did not (P = 0.7934). In the matched treatment group, 48% of patients were deceased by the time monitoring had finished compared to 53% in the unmatched group (P = 0.6094). The immunohistochemistry biomarker for the ERCC1 receptor was found to be a marker that could be used to predict future survival; ERCC1 loss was found to be predictive of poor survival.
NMR Studies Of Mass Transport In High Acid Content Fuel Cell Membranes Based On PBI/Phosphoric Acid
(2004) Chung, S.H.; Durantino, L.; Jayakody, J.R.P.; Zhang, H.; Xiao, L.; Benicewicz, B.; Greenbaum, S.G.
Acid doped polybenzimidazole (PBI) has emerged as a promising candidate for a low-cost and high performance fuel cell membrane material. It has been shown that this polymer electrolyte membrane exhibits high ionic conductivity at temperatures up to 200oC. However,additional progress is still needed for the large-scale application of PBI in fuel cells. Furthermore, the conventional method to prepare acid doped PBI membranes involves a multi-step process while the mechanical properties of the resulting membranes are largely limited by the low molecular weight of PBI used in previous studies. A novel process, previously reported and termed as the PPA process, has been developed to prepare pyridine-based PBI (PPBI) membranes loaded with high levels of phosphoric acid by direct casting of the PPA polymerization solution without isolation or redissolution of the polymers, followed by a sol-gel transition induced by the hydrolysis of PPA intophosphoric acid. In an attempt to understand the ion dynamics in these membranes, two samples of this material prepared in a different manner have been examined by using nuclear magnetic resonance (NMR) techniques over a range of temperatures from 290 to 383 K. The first sample BB1 was prepared by soaking the PBI films in phosphoric acid solutions whereas the second sample BB2 was produced by the new sol-gel process which allows for greater levels of phosphoric acid loading. Using experimental techniques described elsewhere3, 1H (I=�) and 31P (I=�) NMR linewidths, spin-lattice relaxation times T1, and self-diffusion coefficients D for these materials are reported. To obtain consistent and reproducible data, the samples were dried at 423K for 90 minutes. Significant differences in the diffusion coefficients and relaxations times before and after drying are noted. For all samples a single 31P peak centered close to the reference signal from 85% H3P04 was observed. There were no spectral indications of condensed phosphates. In BB1 the line widths and relaxation times show weak temperature dependence in contrast to the data for BB2 where there were indications of motional narrowing and a welldefined T1 minimum. The diffusion data show that protons diffuse faster than the phosphorus carrying species, which means that the inter-phosphate proton transfer is important in these materials. Proton NMR diffusion and T1 data for BB2 are shown at right.
NMR Studies of Mass Transport in High-Acid-Content Fuel Cell Membranes Based on Phosphoric Acid and Polybenzimidazole
(Journal of Electrochemical Society, 2007) Jayakody, J.R.P.; Chung, S.H.; Durantino, L.; Zhang, H.; Xiao, L.; Benicewicz, B.; Greenbaum, S.G.
Mass-transport studies of phosphoric acid (PA)-doped meta-polybenzimidazole (PBI) fuel cell membranes are described. In this study, the fundamental differences in transport properties between m-PBI/PA membranes prepared by conventional imbibing procedures and the polyphosphoric acid (PPA) process are explored. The membranes were characterized by proton conductivity and multinuclear (1H and 31P) magnetic resonance measurements. Both short-range and long-range dynamical processes were investigated by spin?lattice and spin?spin relaxation time measurements and by pulsed ?eld gradient diffusion, respectively. Comparative data for pure PA and PPA are included. The high proton conductivity(0.13 S/cm at 160�C) of the PPA-processed membranes is correlated with rapid proton self-diffusion (3 x 10?6 cm2/s at 180�C). The 31P results reveal the presence of both PA and the dimeric pyrophosphoric acid and indicate strong interaction between the phosphate groups and the m-PBI matrix, with negligible anionic transport for both kinds of membranes. The higher concentration of PA in the PPA-processed membranes and differences in membrane morphology may provide an additional proton-transport mechanism involving rapid exchange between the PA and pyrophosphoric acid species.
Spatial Variation in Trophic Structure of Dominant Fish Species in Lake Dongting, China during Dry Season
(Water, 2018) Yu, J.; Guo, L.; Zhang, H.; Xu, J.; Hu, H.; Xue, T; Luo, C.; Yi, C.; Hu, Y.; De Silva, K.; Xie, P.
Understanding trophic interactions in food webs is crucial to revealing the transfer of substances and energy from primary food sources to consumers in aquatic ecosystems. We hypothesize that the trophic structure of consumers can be significantly affected by primary food sources (pelagic, benthic, and littoral sources) through complex trophic interactions. This study used stable isotope analysis and Bayesian mixing models to estimate the trophic levels of fish consumers and the contributions of primary food sources in the three sub-lakes (Eastern, Southern, and Western Dongting) of Lake Dongting, which have different physical and chemical parameters of water, fish species diversity, and plankton (phytoplankton and zooplankton) density. Results showed the differences in community structures of fish among sub-lakes. Fish trophic levels were significantly higher in Eastern Dongting than those in the two other areas. The contributions of primary food sources to fishes were as follows: the pelagic source was the main basal food source in Eastern Dongting, and littoral and pelagic sources played equally essential roles in Southern Dongting; fishes in Western Dongting relied on more benthic source to growth than those in the two other regions. This study can fill gaps in our knowledge of the influence of the underlying food available on trophic structure of consumers by exploring the role of primary food sources and making the trophic structure of consumers in the aquatic food web highly complicated and diverse through control of the distribution of primary food sources.