1st-2017

Permanent URI for this collectionhttp://repository.kln.ac.lk/handle/123456789/17673

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Author: search.filters.author.Peiris, K.P.P.

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    Ayurvedic management of Branch Retinal Vein Occlusion: a case study.
    (Department of Shalya Shalakya,Gampaha Wickramarachchi Ayurveda Institute,University of Kelaniya,Sri Lanka, 2017) Abegunasekara, N.S.; Peiris, K.P.P.
    Branch Retinal Vein Occlusion (BRVO) is one of the major causes of sudden painless loss of vision after diabetic retinopathy. Two third of patients with ischemic BRVO are prone to blindness.There has been no treatment identied so far to reverse open the blocked vessels to maintain perfusion and the available treatment modality (laser photocoagulation) is not effective in the absence of macular perfusion. The purpose of this study was to evaluate the efcacy of selected Ayurveda modalities in the management of BRVO and to study the pathogenesis of BRVO. A 68 year-old male patient with unilateral BRVO reported to the Shalakya clinic, having a visual acuity 3/60 in right eye and 6/24 in left eye with distorted vision and visual eld defect. His near vision was CF in right eye and N8 in left eye. The patient did not have any other complications such as diabetic, hypertension or any other systemic disease. He was administrated with selected Ayurveda modalities for three (03) months continuously. Treatment protocol consisted of local and systemic therapies. After 14 days of therapy, there was marked improvement of visual acuity. At the end of follow-up period complete remission of symptoms was observed. Thus it is concluded that the treatment protocol which was used to treat the patient was effective in the management of BRVO.
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    Antibacterial activity of two different Prathisaranas against periodontitis.
    (Department of Shalya Shalakya,Gampaha Wickramarachchi Ayurveda Institute,University of Kelaniya,Sri Lanka, 2017) Abegunasekara, N.S.; Peiris, K.P.P.; Sudesh, A.D.H.
    'Kushtaadi Choorna and Shwethamanjana Choorna' are used in the treatment ofDanthamulagatha Roga such as Sheethada, Danthaweshta and Upakusha. These formulations are used specially as a local treatment. Staphylococcus aureus and Methicillin resistant Staphylococcus aureus (MRSA) are main causative organisms of periodontal diseases. The present study was carried out to determine the antibacterial activity of Kushtaadi choorna andShwethamanjana choorna using agar well diffusion method in comparison with standard antibiotic Amoxicillin against the Staphylococcus aureus (ATCC 25923) and Methicillin resistant Staphylococcus aureus (MRSA). The samples of Prathisarana were prepared in ne powder form, Amoxicillin as positive control and triplicates were made for each test. Observation was recorded by measuring the diameter of the inhibitory zones surrounding the wells. According to the results, inhibitory effect of both Prathisarana samples were signicantfor Staphylococcus aureus and Methicillin resistant Staphylococcus aureus (MRSA).
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    Effect of herbal tooth formulation on plaque deposition: a comparative pilot study.
    (Department of Shalya Shalakya,Gampaha Wickramarachchi Ayurveda Institute,University of Kelaniya,Sri Lanka, 2017) Rupasinghe, R.A.A.N.; Peiris, K.P.P.
    Ayurveda and Sri Lankan traditional medical system devote a signicant importance to oral health problems on its preventive aspect rather than curative. The proposed herbal formulation is specied as a dentifrice in Talapathe Piliyam. But it has not been scientically evaluated. Therefore, this study was carried out to evaluate the effectiveness of reducing plaque accumulation on teeth, maintenance of oral hygiene and compare the efcacy of powder with the novel toothpaste. The formation in different forms (paste and powder) was prepared at the laboratory of Sri Lanka Ayurvedic Drug Cooperation, Navinna, Sri Lanka. Thirty patients were selected with written consent from Shalakya OPD by using specic proforma. They were randomly divided into two groups; group A and B (15 patients in each) irrespective of their sex, age, habitat etc. Group A was advised to brush twice a day for two weeks by using the toothpaste and group B from the same formation as powder. Oral Hygiene Index (OHI) and Plaque Index (PI) were used as an objective criteria. The OHI of group A varied as Poor (3.1-6.0) 66.67% , Fair (1.3-3.0) 33.33% and Good (0.0-1.2) 0% prior to the trial and showed as Poor 0%, Fair 86.6% and Good 13.33% after the trail period. In group B; Poor 20% , Fair 80% and Good 0% prior to the trial and showed as Poor 0% , Fair 93.37%, good 6.67% after the trial. The PI of group A varied as Poor (2.0-3.0) 66.67%, Fair (1.0-1.9) 33.33%, Good (0.1-0.9) 0% and Excellent (0) 0% prior to the trial and showed as Poor 0%, Fair 80% , Good 20% and Excellent 0% after the trial period. In group B; Poor 46.67%, Fair 53.33%, Good 0% and Excellent 0% prior to the trial and showed as Poor 0%, Fair 80%, Good 20% and Excellent 0% after the trial. Thus, it can be concluded this toothpaste is more effective in comparison to the tooth powder. However, a long term study would conrm the result of the study.
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    A comparative study on the anti-microbial efficacy of two Ayurveda powders (Prathisarana) used in periodontal diseases
    (Department of Shalya Shalakya,Gampaha Wickramarachchi Ayurveda Institute,University of Kelaniya,Sri Lanka, 2017) Wijebandara, D.M.K.K.; Peiris, K.P.P.; Karunarathna, E.D.C.; Sudesh, A.D.H.
    Kushtadi (KU) and Karanjadi (KR) are prominently used Ayurvedic powders (Prathisarana) in the management of periodontal diseases. This study was carried out for the determination of antimicrobial efcacy of these two drugs using standard Antimicrobial Sensitivity Test against Candida albicans and a fungal culture isolated from a patient. The Antimicrobial Sensitivity Test was performed according to the Well diffusion method having 6mm diameter wells on Sabouraud Dextrose Agar (SDA). Each well was loaded with test drugs mixed in 20μl of sterile distilled water and uconazole 2.5mg / ml as the positive control. According to the results, KR showed an average Inhibition Zone Diameter (IZD) of 20mm for the isolated culture while KU did not show any inhibition. The results were similar for Candida albicans, KR showing IZD 18 mm, KU IZD 0 mm while positive control showed an inhibition of 25 mm. Therefore, it can be concluded that both Candida albicans and the isolated culture were sensitive only for KR making it the only effective drug out of the two drugs tested in this study.
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    Microbiological study of an indigenous mouth wash (Gandusha) used in periodontal diseases.
    (Department of Shalya Shalakya,Gampaha Wickramarachchi Ayurveda Institute,University of Kelaniya,Sri Lanka, 2017) Dewasurendra, D.M.W.; Peiris, K.P.P.; Karunarathna, E.D.C.; Sudesh, A.D.H.
    Mouth wash (Gandusha) is clinically effective in the management of periodontal diseases. This study is an in-vitro analysis on determining the antimicrobial efcacy of this drug using standard Antimicrobial Sensitivity Test against a fungal culture isolated from a patient. The test was performed according to the Well diffusion method having 6mm diameter wells on Sabouraud Dextrose Agar (SDA). Each well was loaded with the test drug mixed in 20μl of sterile distilled water and uconazole 2.5mg / ml was used as the positive control. According to the results, the test drug showed an average Inhibition Zone Diameter (IZD) of 19mm while the positive control showed IZD of 15mm. Therefore, it can be stated that the test drug is more effective than the positive control and the isolated culture is sensitive to the test drug as it had shown an IZD of 19mm while it is intermediate sensitive for the positive control as 15mm comes under Intermediate sensitive range (15-18mm). These results support the claim that the indigenous mouth wash (Gandusha) is effective in the management of periodontal diseases.
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    The efficacy of Rakta Apamargadi Dhooma Varti in the management of Nasa Arsha (Nasal polys).
    (Department of Shalya Shalakya,Gampaha Wickramarachchi Ayurveda Institute,University of Kelaniya,Sri Lanka, 2017) Ranasinghe, R.H.S.; Peiris, K.P.P.
    Nasal Polyps represent a challenging diagnosis for the physician to treat. Management of nasal polyps forms a large part of the workload due to non-availability of successful treatment modalities with reincarnation of removed polypoidal tissues. Among Ayurvedic treatments, fumigation treatment (Dhoopana Kalpana) was used in the management of Nasa Arsa. This study aimed at introducing a new treatment modality with new formulation Rakta Apamargadi Dhooma Varti. It has been practiced clinically in Shalakya clinic at Gampaha Wickramarachchi Ayurveda Hospital, though not statistically evaluated. In the clinical study, 20 patients were selected in age group between 16-60 years irrespective of their sex, religion, occupation and habitat etc. They were randomly divided in to two groups and a detailed research performa was prepared incorporating all the relevant points to study the patient as well as the disease. Group A was treated with Rakta Apamargadi Dhooma Varti for fumigation treatment with Thamalakyadi Phanta and Seetarama Vati. Group B was treated with above internal medicine without fumigation. All of them completed the treatment accurately within two weeks and the follow up study continued up to one month. After the treatment, the size of the Nasa Arsha was assessed on the basis of the anterior rhinoscopic examination with pre and post photographs and by assisting special symptom wise questionnaire, Nasal Obstruction Symptom Evaluation (NOSE) instrument/scale with visual analogue scale and tested blood for WBC/DC levels as special investigation. According to the analysis, fumigation treatment had shown signicant results for nasal obstruction and reducing the size of the polypoidal sprouts. However, while considering the other symptoms such as headache, running nose, sneezing and itching of eyes Group B too has shown considerable improvement.
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    A comparative study on the efficacy of Patoladi Lepa Pratisarana and Mustadi Taila Gandusha in the management of Krimidanta (Dental Caries)
    (Department of Shalya Shalakya,Gampaha Wickramarachchi Ayurveda Institute,University of Kelaniya,Sri Lanka, 2017) Kumaradharmasena, L.S.P.; Peiris, K.P.P.; Kamal, S.V.
    According recent statistics, more than 50% of Sri Lankan and 36% of world population are suffering from Krimidanta (Dental Caries). Dental Caries is a multi-factorial process that affects on hard dental tissues such as enamel, dentin etc. Once it occurs, its manifestations persist throughout life even though the lesion is treated. Therefore, an effective therapy is required in the treatment of Krimidanta at its early stage, which is simple, safe and effective. In this study, Patoladi Lepa and Mustadi Taila were used as research drugs which have been prescribed in Cakkradatta. A total sample of 60 patients were selected at Ayurvedic Teaching Hospital, Borella and Gampaha Wickramarachchi Ayurveda Hospital, Yakkala. They were divided equally into two groups by using simple random sampling method. Group A was treated with 2g of Patoladi Lepa Pratisarana twice a day and Group B was prescribed 20ml of Mustadi Taila Gandusha twice a day for 4 weeks. Both groups showed signicant results in the improvement of Dantashula, Shopha, Mukha Daurgandhyata, Danta Harsha, Animitta Ruja, Salivary pH and OHI-S. Howwever, chalata was improved in Group B patients only. Improvement in Krishnata was not observed in both the therapies. In the view of all the subjective and objective criteria and recurrences of the clinical features, Mustadi Taila Gandusha has shown better effectiveness than Patoladi Lepa Pratisarana. Therefore, these formulations can be used together at the early stage of Krimidanta as a prophylactic measure.