Books and Chapters of Books
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Item Neurogastroenterology and motility disorders in pediatric population(Elsevier, 2019) Rajindrajith, S.; Devanarayana, N.M.; Chanpong, A.; Thapar, N.Motility of the gastrointestinal tract plays a critical role in the maintenance of its many physiological functions. These motility patterns, which vary along the gastrointestinal tract, are achieved by highly coordinated interactions between the neuromusculature of the gut (smooth muscle layers, enteric nervous system, interstitial cells of Cajal), central nervous system, autonomic nervous system, hormones, peptides and the microbiome. Other external factors such as diet, and age related changes in the gastrointestinal tract also, ultimately, affect gastrointestinal motility. A subtle change in any of the above factors could significantly impact on gastrointestinal function leading to pediatric gastrointestinal motility disorders. Here, we review common motility disorders in children and provide an indepth understanding of the pathophysiology and management of these problem. © 2020 Elsevier Inc. All rights reserved.Item Defecation disorders in children: constipation and functional fecal incontinence(Springer International Publishing, 2016) Rajindrajith, S.; Devanarayana, N.M.; Benninga, M.A.Defecation disorders denote a state of altered defecation dynamics leading to an array of clinical presentations. With the currently available epidemiological studies, it is evident that these disorders have become a set of rapidly spreading global health problems. Due to the broadening of the understanding of escalating health-care costs and poor quality of life, these diseases demand attention of clinicians and researchers, more than at any other time in history. However, it is regrettable that only a little guidance is available for health-care professionals to manage these disorders. Most of the therapeutic trials and investigation plans are archaic from the viewpoint of a twenty-first-century clinician and are not evidence based. However, new research ventures are being carried out, and the horizon of the knowledge base is expanding, perhaps indicating a brighter future. In this chapter, we discuss emerging concepts of definitions, epidemiology, pathophysiology, clinical evaluation, and management of defecation disorders in children and adolescents.