Medicine
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This repository contains the published and unpublished research of the Faculty of Medicine by the staff members of the faculty
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Item Infantile glaucoma associated with neonatal rubella(Sri Lanka Medical Association, 1976) de Silva, D.G.H.; Soysa, P.E.; Rajasimman, S.; Vitarana, U.T.; de Silva, D.D.No abstract availableItem Meningococcal septicaemia(Sri Lanka Medical Association, 1976) de Silva, D.D.; de Silva, D.G.H.; Soysa, P.E.; Lamabadusuriya, S.P.No Abstract AvailableItem Sugar intolerance complicating acute gastroenteritis in children(Sri Lanka Medical Association, 1977) de Silva, D.G.H.; Lamabadusuriya, S.P.No abstract availableItem Bilateral pneumothorax following rupture of pneumatocoeles in kerosene aspiration(Sri Lanka Medical Association, 1979) de Silva, D.G.H.; Arulanandham, P.; Talwatte, S.N.No abstract availableItem The Pattern of rheumatic fever in a paediatric unit in Colombo(Sri Lanka Medical Association, 1980) Soysa, P.E.; de Silva, D.G.H.; Ariyananda, P.L.; de Silva, D.D.No abstract availableItem The Prevalence and severity of soil transmitted helminths in an urban slum community in Colombo(Sri Lanka Medical Association, 1981) de Silva, D.G.H.; Jayatilleka, S.M.No abstract availableItem Chronic brucellosis in a farmer(Sri Lanka Medical Association, 1981) de Silva, D.G.H.; Wijeratne, U.No Abstract AvailableItem Pernicious anaemia--a case report(Sri Lanka Medical Association, 1983) Wijesiriwardena, B.C.; de Silva, J.; Jayasinghe, K.S.; Sheriff, M.H.; Dharmadasa, K.Item Experiments in crossing two strains of Anopheles barbirostris van der Wulp 1884 Diptera: Culicidae) in Thailand(SEAMEO Regional Tropical Medicine and Public Health Project, 1983) Choochote, W.; Sucharit, S.; Abeyewickreme, W.Item A Note on adaptation of Anopheles annularis Van Der Wulp, Kanchanaburi, Thailand to free mating in a 30 X 30 X 30 cm cage(SEAMEO Regional Tropical Medicine and Public Health Project, 1983) Choochote, W.; Sucharit, S.; Abeyewickreme, W.No abstract availableItem Disaccharidase activities in jejunal fluid(British Medical Association, 1983) Aramayo, L.A.; de Silva, D.G.H.; Hughes, C.A.; Brown, G.A.; McNeish, A.S.Jejunal fluid and mucosal tissue were obtained simultaneously from the same jejunal site in a group of 29 children by a modified biopsy procedure. Lactase, maltase, and sucrase activities were measured in both fluid and mucosal specimens using the same analytical method. The fluid enzyme activities showed highly significant positive correlations with the same enzyme activity in the relevant tissue samples. Relative concentrations of disaccharidase enzymes represented by sucrase: lactase activity ratios also showed a highly significant positive correlation between fluid and tissue. This close relation suggests that the mucosa is the sole or predominant source of disaccharidase activity in the intestinal fluid. The results of kinetic studies comparing tissue and fluid enzyme characteristics also indicate a mucosal origin for the fluid enzyme activities. We conclude that disaccharidase activities in jejunal fluid reflect closely local tissue values and that these measurements may be useful in assessing mucosal enzyme activity in infants in whom jejunal biopsy is not possibleItem Flubendazole in the treatment of Ascaris lumbricoides and Trichuris trichiura: a comparison of two different regimens with single-dose(Sri Lanka Medical Association, 1984) de Silva, D.G.H.; Lionel, N.D.; Jayatilleka, S.M.No Abstract AvailableItem Congenital lipodystrophy (Seip syndrome) in Sri Lanka(Sri Lanka Medical Association, 1984) de Silva, D.G.H.No abstract availableItem Rota virus associated carbohydrate intolerance in Sri Lankan children(Sri Lanka Medical Association, 1984) de Silva, D.G.H.; Mendis, L.; Soysa, P.No abstract availableItem A Family with the Noonan Syndrome(Ceylon College of Physicians, 1984) de Silva, H.J.; de Silva, C.; Wijesiriwardena, B.C.; Chanmugam, D.; Dharmadasa, K.No Abstract availableItem Anopheles (Cellia) tessellatus; an efficient laboratory vector of Bancroftian filariasis in Sri Lanka(Museum and Reference Centre, SEAMEO-TROPMED National Centre of Thailand, 1985) Abeyewickreme, W.; Ismail, M.M.Item A Study of acute upper gastro-intestinal haemorrhage(Ceylon College of Physicians, 1985) de Silva, H.J.; Fernando, D.P.A.; Wickremasinghe, S.Y.D.; de Silva, P.T.; Dharmadasa, K.Item Drug induced alterations in some rat hepatic microsomal components:a comparative study of four structurally different antimalarials(Pergamon Press, 1985) Thabrew, M.I.; Nashiru, T.O.; Emerole, G.O.Alterations in microsomal drug metabolizing enzymes, microsomal lipids and some serum enzymes following pre-treatment of rats with therapeutic doses of four structurally different antimalarial compounds, chloroquine (CQ), quinine (Q), quinacrine (QK) and primaquine (PQ) have been investigated. CQ and Q significantly decreased the activities of aminopyrene N-demethylase, aniline hydroxylase and both microsomal and cytosolic glutathione S-transferases. Only aniline hydroxylase was markedly decreased by QK, while PQ did not have much effect on any of these enzymes. CQ, Q and QK significantly increased the cholesterol:phospholipid ratio while all four compounds decreased the phosphatidyl choline:sphingomyelin (PC/S) ratio. All the drugs increased the activities of the serum enzymes glutamate-oxaloacetate transaminase, glutamate-pyruvate transaminase and alkaline phosphatase. The possible relationships of these results to structural variations in the four drugs being investigated has been discussedItem Covalent binding and glutathione depletion in the rat following niridazole (ambilhar) pretreatment(Springer-Verlag, 1985) Oduah, I.N.; Thabrew, M.I.; Emerole, G.O.In vivo and in vitro studies with rats have shown that (14C) niridazole (Ambilhar) binds covalently to tissue proteins, but not to nucleic acids. In the in vitro experiments, binding required the presence of NADPH in the incubation medium, suggesting the production of an active metabolite via a cytochrome P-450-mediated reaction. Niridazole also caused significant dose-dependent decreases in liver and kidney glutathione levels, even though it had no apparent effect on blood glutathione. Alteration of tissue glutathione availability by pretreatment with chloracetamide or cysteine respectively either increased or decreased the NADPH-dependent covalent binding. Pretreatment with phenobarbital, 3-methylcholanthrene or cobaltous chloride, which change the rate of metabolism of (14C) niridazole, similarly altered the extent of protein binding. It is shown that the decrease in tissue glutathione concentration is not due to an effect of the drug on the activities of either glucose-6-phosphate dehydrogenase or glutathione-S-transferases. However, there is a significant reduction in glutathione reductase activity in all the tissues studied. The possible relationships between the results obtained and the cytotoxic effects of niridazole have been discussed.Item A Delayed onset cerebellar syndrome complicating falciparum malaria(Sri Lanka Medical Association, 1986) de Silva, H.J.; Gamage, R.; Herath, H.K.; Abeysekera, D.T.; Peiris, J.B.No abstract available