Medicine
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This repository contains the published and unpublished research of the Faculty of Medicine by the staff members of the faculty
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Item The first reported case of co-infection of imported hepatitis E and Plasmodium falciparum malaria in Sri Lanka(Sri Lankan Society for Microbiology, 2023) Senarathne, S.; Rajapakse, S.; de Silva, H.J.; Seneviratne, S.; Chulasiri, P.; Fernando, D.Global travel and tourism, especially across tropical countries, may lead to importation of malaria and other infectious diseases into Sri Lanka. This case report describes the first co-infection of imported hepatitis E and Plasmodium falciparum malaria in a tourist diagnosed in Sri Lanka. The patient was initially diagnosed with uncomplicated P. falciparum malaria and was started on treatment with oral Artemisinin-based Combination Therapy (ACT). Deterioration of hepatic enzymes and hyperbilirubinaemia despite the rapid parasitological response to antimalarials led to further investigation and diagnosis of co-infecting hepatitis E in this patient. The importance of clinicians being vigilant on travel associated co-infections is highlighted to ensure early diagnosis and better patient management.Item Evidence for emerging sulfadoxine-pyrimethamine resistance of Plasmodium falciparum isolated in the Northern Province of Sri Lanka(Sri Lanka Association for the Advancement of Science, 2005) Hapuarachchi, H.A.C.; Dayanath, M.Y.D.; Abeysundara, S.; Bandara, K.B.A.T.; Abeyewickreme, W.; de Silva, N.R.Item The impact of repeated malaria attacks on the school performance of children(American Society of Tropical Medicine and Hygiene, 2003) Fernando, S.D.; Gunawardena, D.M.; Bandara, M.R.; de Silva, D.; Carter, R.; Mendis, K.N.; Wickremasinghe, A.R.The impact of repeated malarial infections on the school performance of children was investigated in 571 school children 6-14 years of age in a malaria-endemic area in southern Sri Lanka where both Plasmodium falciparum and P. vivax infections are prevalent. Malaria infections confirmed by microscopy were monitored over a six-year period. School performance was assessed by two specially designed, school grade-specific, test papers for Sinhala language and mathematics. The scores for Sinhala language and mathematics for each school term test for the year 1997 were obtained. Malarial infections were a major predictor of children's performance in language and mathematics after controlling for parent's education, monthly family income, and house type. The education of the father predicted language scores but not mathematics scores. A child who experienced more than five attacks of malaria scored approximately 15 percent less than a child who experienced less than three attacks of malaria. The data suggest that repeated attacks of malaria have an adverse impact on the school performance of children.Item Skeletal muscle necrosis in severe falciparum malaria(British Medical Association, 1988) de Silva, H.J.; Goonetilleke, A.K.; Senaratna, N.; Ramesh, N.; Jayawickrama, U.S.; Jayasinghe, K.S.; Amarasekera, L.R.No Abstract AvailableItem A Self-limiting midline cerebellar syndrome. Is falciparum malaria the cause?(Sage Publishing, 1988) de Silva, H.J.; Gamage, R.; Herath, H.K.; Peiris, J.B.; Abeysekera, D.T.No Abstract AvailableItem Delayed cerebellar ataxia: a new complication of falciparum malaria?(British Medical Association, 1987) de Silva, H.J.No Abstract AvailableItem A Delayed onset cerebellar syndrome complicating falciparum malaria(Sri Lanka Medical Association, 1986) de Silva, H.J.; Gamage, R.; Herath, H.K.; Abeysekera, D.T.; Peiris, J.B.No abstract available