Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation

Simple item page
dc.contributor.authorKato, N.
dc.contributor.authorLoh, M.
dc.contributor.authorTakeuchi, F.
dc.contributor.authorVerweij, N.
dc.contributor.authorWang, X.
dc.contributor.authorZhang, W.
dc.contributor.authorKelly, T.N.
dc.contributor.authorSaleheen, D.
dc.contributor.authorLehne, B.
dc.contributor.authorLeach, I.M.
dc.contributor.authorDrong, A.W.
dc.contributor.authorAbbott, J.
dc.contributor.authorWahl, S.
dc.contributor.authorTan, S.T.
dc.contributor.authorScott, W.R.
dc.contributor.authorCampanella, G.
dc.contributor.authorChadeau-Hyam, M.
dc.contributor.authorAfzal, U.
dc.contributor.authorAhluwalia, T.S.
dc.contributor.authorBonder, M.J.
dc.contributor.authorChen, P.
dc.contributor.authorDehghan, A.
dc.contributor.authorEdwards, T.L.
dc.contributor.authorEsko, T.
dc.contributor.authorGo, M.J.
dc.contributor.authorHarris, S.E.
dc.contributor.authorHartiala, J.
dc.contributor.authorKasela, S.
dc.contributor.authorKasturiratne, A.
dc.contributor.authorKhor, C.C.
dc.contributor.authorKleber, M.E.
dc.contributor.authorLi, H.
dc.contributor.authorMok, Z.Y.
dc.contributor.authorNakatochi, M.
dc.contributor.authorSapari, N.S.
dc.contributor.authorSaxena, R.
dc.contributor.authorStewart, A.F.
dc.contributor.authorStolk, L.
dc.contributor.authorTabara, Y.
dc.contributor.authorTeh, A.L.
dc.contributor.authorWu, Y.
dc.contributor.authorWu, J.Y.
dc.contributor.authorZhang, Y.
dc.contributor.authorAits, I.
dc.contributor.authorDa Silva Couto Alves, A.
dc.contributor.authorDas, S.
dc.contributor.authorDorajoo, R.
dc.contributor.authorHopewell, J.C.
dc.contributor.authorKim, Y.K.
dc.contributor.authorKoivula, R.W.
dc.contributor.authorLuan, J.
dc.contributor.authorLyytikäinen, L.P.
dc.contributor.authorNguyen, Q.N.
dc.contributor.authorPereira, M.A.
dc.contributor.authorPostmus, I.
dc.contributor.authorRaitakari, O.T.
dc.contributor.authorBryan, M.S.
dc.contributor.authorScott, R.A.
dc.contributor.authorSorice, R.
dc.contributor.authorTragante, V.
dc.contributor.authorTraglia, M.
dc.contributor.authorWhite, J.
dc.contributor.authorYamamoto, K.
dc.contributor.authorZhang, Y.
dc.contributor.authorAdair, L.S.
dc.contributor.authorAhmed, A.
dc.contributor.authorAkiyama, K.
dc.contributor.authorAsif, R.
dc.contributor.authorAung, T.
dc.contributor.authorBarroso, I.
dc.contributor.authorBjonnes, A.
dc.contributor.authorBraun, T.R.
dc.contributor.authorCai, H.
dc.contributor.authorChang, L.C.
dc.contributor.authorChen, C.H.
dc.contributor.authorCheng, C.Y.
dc.contributor.authorChong, Y.S.
dc.contributor.authorCollins, R.
dc.contributor.authorCourtney, R.
dc.contributor.authorDavies, G.
dc.contributor.authorDelgado, G.
dc.contributor.authorDo, L.D.
dc.contributor.authorDoevendans, P.A.
dc.contributor.authorGansevoort, R.T.
dc.contributor.authorGao, Y.T.
dc.contributor.authorGrammer, T.B.
dc.contributor.authorGrarup, N.
dc.contributor.authorGrewal, J.
dc.contributor.authorGu, D.
dc.contributor.authorWander, G.S.
dc.contributor.authorHartikainen, A.L.
dc.contributor.authorHazen, S.L.
dc.contributor.authorHe, J.
dc.contributor.authorHeng, C.K.
dc.contributor.authorHixson, J.E.
dc.contributor.authorHofman, A.
dc.contributor.authorHsu, C.
dc.contributor.authorHuang, W.
dc.contributor.authorHusemoen, L.L.
dc.contributor.authorHwang, J.Y.
dc.contributor.authorIchihara, S.
dc.contributor.authorIgase, M.
dc.contributor.authorIsono, M.
dc.contributor.authorJustesen, J.M.
dc.contributor.authorKatsuya, T.
dc.contributor.authorKibriya, M.G.
dc.contributor.authorKim, Y.J.
dc.contributor.authorKishimoto, M.
dc.contributor.authorKoh, W.P.
dc.contributor.authorKohara, K.
dc.contributor.authorKumari, M.
dc.contributor.authorKwek, K.
dc.contributor.authorLee, N.R.
dc.contributor.authorLee, J.
dc.contributor.authorLiao, J.
dc.contributor.authorLieb, W.
dc.contributor.authorLiewald, D.C.
dc.contributor.authorMatsubara, T.
dc.contributor.authorMatsushita, Y.
dc.contributor.authorMeitinger, T.
dc.contributor.authorMihailov, E.
dc.contributor.authorMilani, L.
dc.contributor.authorMills, R.
dc.contributor.authorMononen, N.
dc.contributor.authorMüller-Nurasyid, M.
dc.contributor.authorNabika, T.
dc.contributor.authorNakashima, E.
dc.contributor.authorNg, H.K.
dc.contributor.authorNikus, K.
dc.contributor.authorNutile, T.
dc.contributor.authorOhkubo, T.
dc.contributor.authorOhnaka, K.
dc.contributor.authorParish, S.
dc.contributor.authorPaternoster, L.
dc.contributor.authorPeng, H.
dc.contributor.authorPeters, A.
dc.contributor.authorPham, S.T.
dc.contributor.authorPinidiyapathirage, M.J.
dc.contributor.authorRahman, M.
dc.contributor.authorRakugi, H.
dc.contributor.authorRolandsson, O.
dc.contributor.authorRozario, M.A.
dc.contributor.authorRuggiero, D.
dc.contributor.authorSala, C.F.
dc.contributor.authorSarju, R.
dc.contributor.authorShimokawa, K.
dc.contributor.authorSnieder, H.
dc.contributor.authorSparso, T.
dc.contributor.authorSpiering, W.
dc.contributor.authorStarr, J.M.
dc.contributor.authorStott, D.J.
dc.contributor.authorStram, D.O.
dc.contributor.authorSugiyama, T.
dc.contributor.authorSzymczak, S.
dc.contributor.authorTang, W.H.
dc.contributor.authorTong, L.
dc.contributor.authorTrompet, S.
dc.contributor.authorTurjanmaa, V.
dc.contributor.authorUeshima, H.
dc.contributor.authorUitterlinden, A.G.
dc.contributor.authorUmemura, S.
dc.contributor.authorVaarasmaki, M.
dc.contributor.authorvan Dam, R.M.
dc.contributor.authorvan Gilst, W.H.
dc.contributor.authorvan Veldhuisen, D.J.
dc.contributor.authorViikari, J.S.
dc.contributor.authorWaldenberger, M.
dc.contributor.authorWang, Y.
dc.contributor.authorWang, A.
dc.contributor.authorWilson, R.
dc.contributor.authorWong, T.Y.
dc.contributor.authorXiang, Y.B.
dc.contributor.authorYamaguchi, S.
dc.contributor.authorYe, X.
dc.contributor.authorYoung, R.D.
dc.contributor.authorYoung, T.L.
dc.contributor.authorYuan, J.M.
dc.contributor.authorZhou, X.
dc.contributor.authorAsselbergs, F.W.
dc.contributor.authorCiullo, M.
dc.contributor.authorClarke, R.
dc.contributor.authorDeloukas, P.
dc.contributor.authorFranke, A.
dc.contributor.authorFranks, P.W.
dc.contributor.authorFranks, S.
dc.contributor.authorFriedlander, Y.
dc.contributor.authorGross, M.D.
dc.contributor.authorGuo, Z.
dc.contributor.authorHansen, T.
dc.contributor.authorJarvelin, M.R.
dc.contributor.authorJorgensen, T.
dc.contributor.authorJukema, J.W.
dc.contributor.authorKähönen, M.
dc.contributor.authorKajio, H.
dc.contributor.authorKivimaki, M.
dc.contributor.authorLee, J.Y.
dc.contributor.authorLehtimäki, T.
dc.contributor.authorLinneberg, A.
dc.contributor.authorMiki, T.
dc.contributor.authorPedersen, O.
dc.contributor.authorSamani, N.J.
dc.contributor.authorSorensen, T.I.
dc.contributor.authorTakayanagi, R.
dc.contributor.authorToniolo, D.
dc.contributor.authorBIOS-consortium
dc.contributor.authorCARDIo GRAMplusCD
dc.contributor.authorLifeLines Cohort Study
dc.contributor.authorInterAct Consortium
dc.contributor.authorAhsan, H.
dc.contributor.authorAllayee, H.
dc.contributor.authorChen, Y.T.
dc.contributor.authorDanesh, J.
dc.contributor.authorDeary, I.J.
dc.contributor.authorFranco, O.H.
dc.contributor.authorFranke, L.
dc.contributor.authorHeijman, B.T.
dc.contributor.authorHolbrook, J.D.
dc.contributor.authorIsaacs, A.
dc.contributor.authorKim, B.J.
dc.contributor.authorLin, X.
dc.contributor.authorLiu, J.
dc.contributor.authorMärz, W.
dc.contributor.authorMetspalu, A.
dc.contributor.authorMohlke, K.L.
dc.contributor.authorSanghera, D.K.
dc.contributor.authorShu, X.O.
dc.contributor.authorvan Meurs, J.B.
dc.contributor.authorVithana, E.
dc.contributor.authorWickremasinghe, A.R.
dc.contributor.authorWijmenga, C.
dc.contributor.authorWolffenbuttel, B.H.
dc.contributor.authorYokota, M.
dc.contributor.authorZheng, W.
dc.contributor.authorZhu, D.
dc.contributor.authorVineis, P.
dc.contributor.authorKyrtopoulos, S.A.
dc.contributor.authorKleinjans, J.C.
dc.contributor.authorMcCarthy, M.I.
dc.contributor.authorSoong, R.
dc.contributor.authorGieger, C.
dc.contributor.authorScott, J.
dc.contributor.authorTeo, Y.Y.
dc.contributor.authorHe, J.
dc.contributor.authorElliott, P.
dc.contributor.authorTai, E.S.
dc.contributor.authorvan der Harst, P.
dc.contributor.authorKooner, J.S.
dc.contributor.authorChambers, J.C.
dc.date.accessioned2015-11-05T10:42:29Z
dc.date.available2015-11-05T10:42:29Z
dc.date.issued2015
dc.descriptionIndexed in MEDLINE, SCI, SCI Expanded, BIOSIS Previewsen_US
dc.description.abstractWe carried out a trans-ancestry genome-wide association and replication study of blood pressurephenotypes among up to 320,251 individuals of East Asian, European and South Asian ancestry. We find genetic variants at 12 new loci to be associated with blood pressure (P = 3.9 × 10(-11) to 5.0 × 10(-21)). The sentinel blood pressure SNPs are enriched for association with DNAmethylation at multiple nearby CpG sites, suggesting that, at some of the loci identified, DNAmethylation may lie on the regulatory pathway linking sequence variation to blood pressure. The sentinel SNPs at the 12 new loci point to genes involved in vascular smooth muscle (IGFBP3, KCNK3, PDE3A and PRDM6) and renal (ARHGAP24, OSR1, SLC22A7 and TBX2) function. The new and known genetic variants predict increased left ventricular mass, circulating levels of NT-proBNP, and cardiovascular and all-cause mortality (P = 0.04 to 8.6 × 10(-6)). Our results provide new evidence for the role of DNA methylation in blood pressure regulation.en_US
dc.identifier.citationNature Genetics.2015;47:1282 - 1293en_US
dc.identifier.issn1061-4036 (Print)
dc.identifier.issn1546-1718 (Electronic)
dc.identifier.urihttp://repository.kln.ac.lk/handle/123456789/10242
dc.language.isoen_USen_US
dc.publisherNature Publishing Companyen_US
dc.subjectgenetic loci influencing blood pressureen_US
dc.titleTrans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylationen_US
dc.typeArticleen_US

Files

License bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
52 B
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Journal/Magazine Articles