Interleukin 6 is a prognostic indicator of outcome in severe intra-abdominal sepsis

dc.contributor.authorPatel, R.T.en_US
dc.contributor.authorDeen, K.I.en_US
dc.contributor.authorYoungs, D.en_US
dc.contributor.authorWarwick, J.en_US
dc.contributor.authorKeighley, M.R.en_US
dc.date.accessioned2014-10-29T09:11:34Z
dc.date.available2014-10-29T09:11:34Z
dc.date.issued1994en_US
dc.descriptionIndexed in MEDLINE
dc.description.abstractLevels of plasma cytokines and circulating endotoxin were assessed in 41 patients with severe intra-abdominal sepsis. Comparison was made with the Acute Physiology And Chronic Health Evaluation (APACHE) II scoring system. Blood samples were taken within 24 h of onset of the sepsis syndrome and at serial times thereafter. Increased levels of interleukin (IL) 6 (range 50-25,500 pg/ml) were detectable in all patients with sepsis. Eighteen of the 19 deaths were attributable to sepsis and higher levels of IL-6 at the onset of the sepsis syndrome correlated with a poor outcome. The sensitivity of IL-6 concentration in predicting mortality was 86.4 per cent with a specificity of 78.9 per cent and an overall correct classification rate of 82.9 per cent. IL-6 level was a better predictor than APACHE II score (sensitivity 72.7 per cent, specificity 57.9 per cent, correct classification rate 65.9 per cent). Levels of tumour necrosis factor alpha, IL-1 beta and endotoxin did not correlate with mortality rate. Plasma IL-6 concentrations may help in planning future strategies to decrease the mortality rate associated with sepsis.en_US
dc.identifier.citationBritish Journal of Surgery. 1994; 81(9): pp.1306-08en_US
dc.identifier.departmentSurgeryen_US
dc.identifier.issn0007-1323 (Print)en_US
dc.identifier.issn1365-2168 (Electronic)en_US
dc.identifier.urihttp://repository.kln.ac.lk/handle/123456789/1220
dc.subjectBacterial Infections
dc.subjectBacterial Infections-mortality
dc.subjectEndotoxins-blood
dc.subjectInterleukin-1-blood
dc.subjectInterleukin-6-blood
dc.subjectRisk Factors
dc.subjectTumor Necrosis Factor
dc.titleInterleukin 6 is a prognostic indicator of outcome in severe intra-abdominal sepsisen_US
dc.typeArticleen_US

Files

License bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description: