Medicine
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This repository contains the published and unpublished research of the Faculty of Medicine by the staff members of the faculty
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Item Content analysis of policy documents related to non-communicable diseases prevention and control in Sri Lanka: a developing country in the South-East Asia(F1000 Research, 2024) Talagala, I.; Abeysena, C.; Wickremasinghe, R.BACKGROUND: Health policies form the foundation for provisioning best level care and are important for all stakeholders including patients and healthcare providers. Health policy analysis and evaluation allows policy makers to improve an existing policy, terminate a non-effective policy and to successfully implement future policies. The objective was to assess the coherence between the two local policy documents on NCD prevention and control in Sri Lanka, the national NCD policy (NCD policy) and the multisectoral action plan (MSAP), and to assess the consistency of MSAP with the global action plan for NCDs. METHODS: The content analysis of the NCD policy and MSAP of Sri Lanka was conducted based on the modified criteria developed to the ‘Analysis of determinants of policy impact’ model, by two reviewers independently. Coherence between MSAP and the global NCD action plan were also assessed by two reviewers independently. Consensus for discrepancy was achieved through discussion. RESULTS: Accessibility was the strongest criteria for the NCD policy, while, resources and obligations were the weakest. Goals and monitoring and evaluation criteria were the strongest in the MSAP. Requirement for improvement were identified in policy background, goals, monitoring and evaluation, and public opportunities for the NCD policy. Accessibility, policy background, resources, public opportunities and obligations require further improvement in the MSAP. The MSAP is well coherent with the global road map for NCD prevention and control. CONCLUSION: Policy documents related to NCD prevention and control in Sri Lanka are coherent with the global action plan, while, there are areas within the local policy documents that need to be improved to enhance the coherence between the local documents. Lessons learnt by this activity need to be utilized by Sri Lanka and other countries to improve the uniformity between the NCD policy documents within the country as well as internationally.Item Healthy lifestyle profile scale for elderly: A novel tool to assess healthy lifestyle among young elderly live in South Asian settings(Medknow Publications, 2024) Jayasinghe, V.; Ferdinando, R.; Abeysena, C.BACKGROUND: Many lifestyle modification interventions have been introduced for young elderly population (aged from 60 to 74 years) in Sri Lanka to improve their health and well being. However, little is known about the outcome of those interventions as there is no valid tool available to measure the level of a healthy lifestyle. This study was conducted to develop and validate a new tool to assess the level of healthy lifestyle among young elderly in Sri Lanka. MATERIALS AND METHODS: An operationalized definition of the healthy lifestyle was formulated. Items for the tool were identified following a literature review, key informant interviews, and focus group discussions. The content validity of the tool was ensured by the panel of experts. Both exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) were conducted to explore factor structure and construct validity, respectively. The internal consistency, test–retest, and interobserver reliabilities of the tool were also assessed. RESULTS: Sixty two items were identified initially, and they were reduced to 31 based on experts’ opinion. Out of those, 28 items were loaded into 8 factors during the EFA. The results of the CFA showed a satisfactory model fit. Internal consistency (Cronbach’s alpha >0.7), test–retest, and interobserver reliabilities (Interclass correlation coefficients >0.7) were also found to be satisfactory. CONCLUSIONS: The tool was named the Healthy Lifestyle Profile Scale for Elderly (HLPSE). The HLPSE is a valid and reliable tool to assess the level of healthy lifestyle among Sri Lankan young elderly.Item Development of a complex intervention package for dengue prevention(Ministry of Health, Sri Lanka, 2022) Rajapaksha, R.M.N.U.; Abeysena, C.; Balasuriya, A.; PannilaHetti, N.; Alagiyawanna, A.; Manilgama, S.INTRODUCTION: Complex interventions are widely used in public health practices with noteworthy health impacts. Communication for Behavioural Impact (COMBI) plan is an effective method directed at enacting behaviour change to benefit health and social development which encourage precise behavioural outcomes and is effective in planning a behavioural change for dengue control. The aim of this study was to develop an intervention package to change the behaviour to prevent dengue in one of the highest dengue-endemic areas of Sri Lanka. METHODS: The development of the intervention package was formulated according to the two phases, the ‘Theoretical phase’ and ‘Modelling phase’ of the framework for ‘Developing and Evaluating Complex Interventions’. World Health Organization’s 10 key steps in planning COMBI strategies were followed in order to develop the present intervention package. A situational market analysis was conducted in the highest dengue-endemic area in Kurunegala district to identify the Specific Behavioural Objectives (SBOO) for the COMBI plan. The development of the COMBI plan was conducted using the mixed methodological approach including quantitative and qualitative designs. RESULTS: The overall goal of the COMBI plan was to decrease the morbidity and mortality due to dengue illness by improving the dengue prevention behaviours among householders. The SBOO for the plan were to improve the proper waste management practices according to the ‘3R concept’ (Reduce, Reuse and Re-cycling) and to improve the dengue prevention practices by 30 minutes of weekly cleaning. The strategies of intervention package were to conduct a community empowerment program to improve household waste management and weekly practices on dengue prevention by conducting administrative mobilization and public relationship, public advocacy, community mobilization, personal selling, advertising, and point of service promotion during follow-up. CONCLUSION: Developing a COMBI plan for an area after the identification of SBOO would be feasible to implement in order to empower the community to prevent dengue and improve community health services.Item Development and assessment of psychometric properties of model medication adherence (MMA) questionnaire to measure adherence to oral medication among patients with type 2 diabetes mellitus(College of Community Physicians of Sri Lanka, 2023) Perera, S.; Abeysena, C.INTRODUCTION: Medication adherence among patients with type 2 diabetes (DM) is assessed in everyday clinical practice. OBJECTIVES: To develop a questionnaire to measure adherence to oral medication among patients with DM and to assess its psychometric properties METHODS: The “Model Medication Adherence (MMA)” questionnaire was developed using the evidence from literature review and interviews with key stakeholders and patients. Answers were set on a five-point Likert scale that scored from 1 to 5, with 15-73 as the possible range of the total score. MMA was drafted in English and translated to Sinhala language by forward- backward translation. A descriptive cross-sectional study was carried out among adult patients with type 2 DM who attended clinics in Gampaha District General Hospital (DGH). A sample of 150 patients was recruited consecutively. The construct validity of MMA was assessed by Exploratory Factor Analysis (EFA) through Principal Component Analysis (PCA) with Varimax rotation RESULTS: EFA yielded four factors; sick role behaviour, autonomy, forgetfulness, and barriers that explained 64.36% of the variance of the total score of MMA. Internal consistency was acceptable (Cronbach’s alpha 0.73). The testretest reliability coefficient was 0.85 (p=0.01). Acceptability of the MMA was established by non-response items (none) and the time taken to complete (20 minutes). CONCLUSIONS & RECOMMENDATIONS: MMA is a simple valid questionnaire that adds a novel concept to the adherence literature; sick role and autonomy. It has a good factor structure with established construct validity and is recommended to be used in the clinical setting.Item Health seeking behaviours, dengue prevention behaviours and community capacity for sustainable dengue prevention in a highly dengue endemic area, Sri Lanka(BioMed Central, 2023) Rajapaksha, R.M.N.U.; Abeysena, C.; Balasuriya, A.INTRODUCTION: Dengue has become a major health problem in globally as well as locally. The delay in health-seeking is significantly associated with complications leading to severe dengue and active engagement of communities needs to minimize the delays in management to control epidemics. The aim of the study was to evaluate the relationship between sociodemographic characteristics and householders' Health-Seeking Behaviours (HSB), Dengue-Prevention Behaviours (DPB), and Community Capacities (CC) for sustained dengue prevention in Sri Lanka, a country with a high dengue endemicity. METHODS: A cross-sectional analytical study was carried out in a district with the highest dengue endemicity from January to April 2019. Of the householders, 532 were chosen randomly. A pre-tested, validated, and interviewer-administered questionnaire was used to assess HSB and DPB. The HSB was assessed using three aspects, initial response for fever management, the duration of blood testing and initial response if suspected dengue. The DPB assessment was evaluated using 'waste, outdoor water container, indoor water container, roof gutter and water storage management'. 'Dengue Community Capacity Assessment Tool', with 14 key items was used to assess the level of community capacity for dengue prevention. Out of the total, ≥ 50% was considered as an "adequate" HSB, DPB and CC. Multiple logistic regression was performed to control confounding effects. The results were expressed as adjusted Odds-Ratios (aOR) and 95% Confidence Intervals (CI). RESULTS: The response rate was 93.2% (n = 496). Among them, 44.6% (n = 221) had adequate overall HSB, and 19.2% (n = 95) had adequate DPB. Householders who have ≤ 4 family members are 1.74 times (aOR = 1.74; 95% CI: 1.17 - 2.61) more likely to have adequate HSB and 1.85 times (aOR = 1.85; 95% CI: 1.11 - 3.09) more likely to have adequate DPB. The age group of 46 to 70 years' individuals (aOR = 1.74; 95% CI:1.12 - 2.92), and who engaged in employment (aOR = 1.68; 95% CI: 1.05 - 2.67) were more likely to have adequate DPB than the group of 18 to 45 years and the non-employed individuals respectively. Of them, 24.6% (n = 122) perceived that they have adequate CC. The householders who have per-capita income < USD 50 are 1.95 times (aOR = 1.95; 95%CI:1.11 - 3.40) more likely to have adequate CC. CONCLUSION: The HSB, DPB and CC need to be improved to change the behaviour for sustainable dengue prevention and community capacity-building programmes need to be conducted in the Kurunegala district, Sri Lanka.Item Incidence management system of the healthcare institutions for disaster management in Sri Lanka(BioMed Central, 2023) Rajapaksha, N.U.; Abeysena, C.; Balasuriya, A.; Wijesinghe, M.S.D.; Manilgama, S.; Alemu, Y.A.BACKGROUND: Incident management systems and disaster planning processes facilitate maximal use of available resources. Evaluation of the Incident Command System (ICS) is one of the top five key areas of research priority in the field of surge. The study was aimed at assessing the disaster preparedness and ICS of the public healthcare institutions for the disaster management in a disaster-prone district of Sri Lanka. METHODS: A descriptive cross-sectional study was conducted among all public sector healthcare institutions (n = 74), including curative-healthcare institutions (n = 46) which have inward-care facilities for patient care and preventive healthcare institutions (n = 28) in Kurunegala district, Sri Lanka from May-September 2019 using a validated interviewer administered questionnaire which was based on 'CO-S-TR Model' for ICS assessment including 'Clear need for increased capacity (≤25%), Basic level (26 - 50%), Moderate level (51 - 75%) and High level (>75%)'.RESULTS: Focal points for disaster management were nominated by the majority of the curative sector (n = 33; 76.7%) and preventive sector (n = 19; 73.1%) healthcare institutions. A written disaster preparedness and response plans were available in 72% (n= 31) curative sector and 76% (n= 19) preventive sector institutions. The higher proportion of the curative sector institutions had moderate level capacity in the area of providing treatment, and basic level capacities were in the areas of 'staff mobilization, coordination of activities, supplying of special needs, triage of cases and transportation'. There is a clear need for improvement in the areas of communication commanding, management of controlling the incidence and tracking of the cases in the curative sector. The majority of the preventive sector institutions had moderate level capacity in commanding, control, coordination and tracking of cases. The basic level capacity in the areas of staff mobilization, stuff management and triage of cases. There is a clear need for improvement in the areas of communication in preventive sector. Of the public sector healthcare institutions, the higher proportion of the preventive sector (n = 20; 76.9%) and curative sector (n = 29; 67.4%) had basic level overall surge capacity of ICS for disaster management. CONCLUSION: Coordination, communication, commanding, management of controlling the incidence and tracking of cases following outbreaks need to be improved and capacity development programmes could implement to develop the preparedness for future disasters.Item Success and challenges of health systems resilience-enhancing strategies for managing Public Health Emergencies of International Concerns (PHEIC): A systematic review protocol(BMJ Publishing Group Ltd, 2022) Rajapaksha, R.M.N.U.; Khatri, R.B.; Abeysena, C.; Wijesinghe, M.S.D.; Endalamaw, A.; Thomas, T.K.; Perera, N.; Rambukwella, R.; de Silva, G.; Fernando, M.; Alemu, Y.A.Introduction: Health systems resilience is the ability to prepare, manage and learn from a sudden and unpredictable extreme change that impacts health systems. Health systems globally have recently been affected by a number of catastrophic events, including natural disasters and infectious disease epidemics. Understanding health systems resilience has never been more essential until emerging global pandemics. Therefore, the application of resilience-enhancing strategies needs to be assessed to identify the management gaps and give valuable recommendations from the lessons learnt from the global pandemic. Methods: The systematic review will be reported using the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA-P) protocols guideline. Reporting data on World Health Organization (WHO) health system building blocks and systematic searches on resilience enhancing strategies for the management of Public Health Emergencies of International Concerns (PHEIC) after the establishment of International Health Regulations (IHR) in 2007 will be included. The search will be conducted in PubMed, Scopus, Web of Science and Google Scholar ETHICS AND DISSEMINATION: Ethics approval and safety considerations are not applicable. Pre-print of the protocol is available online, and the screening of the articles will be done using Rayyan software in a transparent manner. The findings will be presented at conferences and the final review's findings will be published in a peer-reviewed international journal and will be disseminated to global communities for the application of successful management strategies for the management of future pandemics.Item Risk factors for neonatal sepsis in secondary and tertiary care hospitals of a district in Sri Lanka: A Case-control study(IOS Press, 2021) Jayasinghe, C.; Abeysena, C.OBJECTIVE: The aim of this study was to determine the risk factors for neonatal sepsis. Methods A case-control study was performed in secondary and tertiary care hospitals of a district in Sri Lanka. Neonates who diagnosed with sepsis based on clinical criteria or culture positivity were taken as the case group (n = 240) and neonates born during the same period who had not been diagnosed with sepsis were taken as the control group (n = 240). The controls were recruited from the community. The study instruments were, pretested interviewer administered questionnaire, a check list and record sheets. Multiple logistic regression analysis was performed. The results were expressed as odds ratios (OR) with the 95% confidence intervals (CI). Results The independent risk factors for neonatal sepsis were history of abortions, still birth, and early neonatal deaths (OR: 6.78; 95% CI: 3.2-14.3), registration of pregnancy after 8 weeks of gestation (OR: 1.91; 95% CI: 1.07-3.4), total antenatal clinic visits ≤4 (OR: 7.18; 95% CI: 2.1-24.5), history of maternal fever prior to the week of delivery (OR: 2.74; 95% CI: 1.25-6.0) leaking amniotic fluid >18 hours (OR: 10.0; 95% CI: 2.1-47.4), performed >3 vaginal examinations before delivery (OR: 3.28; 95% CI: 2.1-24.5), meconium stained amniotic fluid (OR: 10.57; 95% CI: 3.7-29.7), mode of delivery by cesarean section, forceps or vacuum (OR: 2.33; 95% CI: 1.4-3.9), time of birth of the neonate being during on-call hours (OR: 2.12; 95% CI: 1.3-3.5), being a male baby (OR: 1.74; 95% CI: 1.1-2.8), and birth weight <2,500 g (OR: 5.17; 95% CI: 2.8-9.6) of neonates. Conclusion Most of the identified risk factors for neonatal sepsis were modifiable. Stringent implementation of guidelines and protocols would prevent neonatal sepsis. © 2021 Georg Thieme Verlag. All rights reserved.Item Evidence-based and epidemiological interpretation of the diagnosis of SARS-COV-2(Sri Lanka Medical Association, 2021) Abeysena, C.; Gamage, A.INTRODUCTION AND OBJECTIVES: Diagnostic tests are never perfect; hence cannot definitely tell whether the disease is present or absent which leads to inaccurate decisions by healthcare workers. The key metrics in interpreting the accuracy are sensitivity and specificity and the test performance measures of positive-predictive-value(PPV) and negative-predictive-value (NPV). Positive and negative predictive values of diagnostic tests vary depending upon the pre-test probability. This paper aims to compile the evidence generated and facilitate the epidemiological interpretation of diagnostic laboratory testing available for COVID-19 pandemic. METHODS: We searched systematic reviews published, especially Cochrane reviews and evidence summaries. Diagnostic accuracy studies were searched when there were no published systematic reviews. PPV, NPV and its 95% confidence intervals (CI) were calculated for the reported sensitivities and specificities and assumed pre-test probability levels. RESULTS: At a low pre-test probability level, PPV is 50%(95%CI: 28%-72%) when we assume 56% sensitivity of the antigen test. If the sensitivity is low, PPV will be low and vice versa; however, the NPV is 69.3% (95%CI: 67%-71%). Considering RT-PCR test PPV is 28.6%(95%CI: 13%-52% at a low pre-test probability level) when we assume 40% sensitivity. Assuming RT-PCR sensitivity is 95%, PPV is 47.4% (95%CI: 32%-63%), NPV is 62.3%(95%CI: 60.6% to 63.9%). Further, assuming that the sensitivity of the RT-PCR is 95%, NPV is 95.2%(95%CI: 93.1% to 96.7%). CONCLUSION: In low resource settings symptoms, signs, basic laboratory and other investigations can be used to screen COVID-19 patients and interpretation of the results of the antigen and RT-PCR test for better diagnosis.Item Evidence-based and epidemiological interpretation of the diagnosis of SARS-COV-2(College of Community Physicians of Sri Lanka, 2021) Abeysena, C.; Gamage, A.U.Introduction: Diagnostic tests are never perfect, leading to inaccurate decisions by healthcare workers. Study aimed to compile the evidence and facilitate the epidemiological interpretation of testing available for the COVID-19. Methods: Published systematic reviews, especially Cochrane reviews and evidence summaries were used. Positive-predictive-values (PPV), negative-predictive-values (NPV), and its 95% confidence intervals (CI) were calculated following application to a hypothetical cohort of 1000 patients, the reported sensitivities and specificities and assumed pre-test probability levels. Results: At a low pre-test probability level, PPV is 63.6%(95%CI: 37.8%-83.5%) when assumed 72%sensitivity of the antigen test among symptomatic patients and 60.0% 95%CI: 33.3%-81.8%) when assumed 58% sensitivity of the antigen test among asymptomatic patients. If the sensitivity is low, PPV will become a low value. PPV is high with a higher pre-test probability level; however, the NPV is 78%(95%CI: 75.5%-80.4%) among symptomatic and 70.3%(95%CI: 68%-72.4%) among asymptomatic patients. PPV is 44.4% (95%CI: 28.6%-61.5% at a low pre-test probability level) when assumed 80% sensitivity for the RT-PCR test. Further, assuming that the sensitivity of 95%, PPV is 47.4% (95%CI: 32%-63%). At a higher pre-test probability level, the NPV is 83.2% (95%CI: 80.6%-85.5%) when assumed 80% sensitivity. Further, the sensitivity of the RT-PCR is 95%, NPV is 95.2%(95%CI: 93.1% to 96.7%). Conclusions: With a low pre-test probability, positive results should be interpreted cautiously and need a second specimen tested for confirmation for both Ag and PCR testing. With higher pre-test probability, the confidence in negative COVID-19 test results is low. Therefore, a combination of symptoms, signs, laboratory investigations can be used with antigen and RT-PCR tests, for diagnosis of COVID-19.