Medicine
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This repository contains the published and unpublished research of the Faculty of Medicine by the staff members of the faculty
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Item Presenting symptoms/conditions and selected aspects of health care quality at the Outpatient Department (OPD) of the Wickramarachchi Ayurvedic Hospital, yakkala(College of the Community Physicians of Sri Lanka, 2007) Wanigasekara, C.; Weerasinghe, P.; Weerasinghe, A.; Weerasooriya, S.; Wellagiriya, S.; Wickramarathne, S.; Wijerathne, B.; Abeysena, C.OBJECTIVE: To describe the presenting symptoms/conditions and selected aspects of health care quality of the Outpatient Department (OPD) of the Wickramarachchi Ayurvedic Hospital. METHODOLOGY: A descriptive cross sectional study was conducted on patients seeking treatment from the CPD oi the Wickramarachchi Ayurvedic Hospital. Yakkala between February to April 2007. A pre-tested interviewer administered questionnaire was used to gather information from 250 patients. RESULTS: Fever, cold and respiratory symptoms (44.2%; n=46), musculoskeletal complaints (28.8%; n=30) and dermatological conditions (14.4%; n=15) were the commonest presentations among persons up to 40 years old. Musculoskeletal complaints (26.8%; n=38). lever, cold and respiratory symptoms (24.6%; n=35) diabetes and hypertension (20.4%; n=29) and eye problems (9.8%; n=14) were the commonest presentations among persons above 40 years. Out of 250 patients, 56(22.4%) had visited the Ayurvedic Hospital as the first preference for the current illness and the balance 194(77.6%) patients had taken treatment from other health care institutions. The majority (86%: =168) sought ayurvedic medicine after taking western medicine. The most common reason for giving up previous treatment methods was treatment failure (69%; n=135). The distance between home and the hospital was <10 km for 52.4%(n=137) patients and >20 km for 11.6%(n=54) patients. Median total expenditure for one visit to the Ayurvedic hospital was Rs.200 (Range Rs. 00500 to 3000.00) and 57.6%(n=144) had spent Rs.100-500 for one visit. Median waiting time for consultation was 90 minutes (Range 5 — 300min). Consultation time was <5 minutes in 52%(n=131) and >10minutes in 24%(n=60) of patients. Two hundred and seven (83%) patients were satisfied with treatment given and 224 (69.6%) on facilities provided by the Ayurvedic hospital. Statistically significant associations were observed between high satisfaction and low educational level (p<0.001) and previous treatment failure from other systems (p<0.001). CONCLUSION: Patients seek ayurvedic treatment for various symptoms/diseases irrespective of their severity. patient's age and the distance to the hospital. The commonest reason for seeking ayurveda treatment was treatment failure at other methods. A majority were satisfied with the treatment provided and facilities available.Item High serum total IgE in children in geohelminthic endemic setting(Sri Lanka Medical Association, 2008) Amarasekera, N.D.D.M.; Gunawardena, N.K.; de Silva, N.R.; Weerasinghe, A.BACKGROUND: Elevated levels of total IgE (tlgE) in serum are characteristic of atopic diseases. However, the usefulness of tlgE in diagnosing atopic diseases in children living in areas endemic for helminth infections is not well established. OBJECTIVE: To assess the effect of geohelminth infections on serum tlgE levels in children with atopic diseases. DESIGN, SETTING AND METHODS: A total of 640 children in grade 5 were recruited from 17 schools in the Western Province. Data regarding atopic diseases were collected by a standard questionnaire. Screening for helminth infections was done by examining their stool samples by modified Kato-Katz technique. Serum tlgE was measured by fluoroenzymeimmunoassay. RESULTS: The mean age in the study population was 10 years (SD±0.3). The prevalence of geohelminth infection was 15.5%. Trichuris trichiura (14.3%) was the most common, followed by Ascaris lumbricoides (4.2%) and hookworm (0.2%). Mixed infection was detected in 20.3% of infected children. The cumulative prevalence of atopic diseases was 33.7%. Prevalence of asthma, rhinitis and eczema was 17%, 21.4% and 5% respectively. Geometric mean (GM) for tlgE for the geohelminth infected group (1039.9kU/L) was significantly higher than that of the non-infected group (575.4kU/L) (p=0.004). It was also higher in the allergic group (933.3kU/L) than in the non-allergic group (639.7kU/L) but the difference was not statistically significant (p=0.068). CONCLUSION: In the presence of geohelminth infections, raised IgE may be due to geohelminth infection or atopic diseases or both. Therefore, serum tlgE may not be a useful marker for allergic diseases in children living in areas endemic for geohelminth infections.Item Prevalence of atopic diseases among school children in Western Province(University of Kelaniya, 2007) Amarasekera, N.D.D.M.; Gunawardena, N.K.; de Silva, N.R.; Weerasinghe, A.Background : Atopic diseases such as asthma, rhinitis and eczema in children are major public health problems in developed, industrialized countries as well as in some developing countries. Our objective was to assess the prevalence of atopic diseases in schoolchildren in grade 5 in the Western Province of Sri Lanka. Method : Schoolchildren in grade 5 were selected by stratified - random sampling frbm 17 schools in the Western Province. Internationally validated ISAAC (International Study of Asthma and Allergies in Childhood) questionnaire, filled by the parent or guardian was used to collect details regarding atopic diseases. Results : A total of 640 schoolchildren were recruited. Five hundred ~nd eleven (79.8%) returned the completed questionnaire. The mean age was I 0 years (SD ± 0.3) and 55.9% of the study population was boys. Prevalence of asthma, rhinitis and eczema was 17%, 21.4% and 5% respectively, while 33.7% had one or more diseases, Thirty three (21.4%) of the children with an atopic disease was on long term treatment. Only the prevalence of allergic rhinitis showed a statistically significant difference between the two sexes, being more common in boys. Less than 30% of affected children's parents recognized that their child had either asthma or rhinitis, whereas a higher number of parents (54.2%) recognized that their child had eczema. Among children with asthma, 44.4% had rhinitis and wheezing was severe enough to disturb their sleep in 52.4% of children. Conclusion: One in 3 children in grade 5 had either asthma or rhinitis or eczema, but parental recognition of these conditions was poor. Atopic diseases are a significant health problem among schoolchildren in the Western Province.Item Twin pregnancy chorionicity determination in a tertiary care setting(Sri Lanka Medical Association, 2013) Dias, T.; Weerasinghe, A.; Amarathunga, P.; de Silva, C.; Thilaganathan, B.Ultrasound determination of chorionicity is most reliable before 14 weeks and subsequently reduces in accuracy with advancing gestation. The aim of this study was to evaluate the accuracy of chorionicity determination in a birth cohort of twin pregnancies. Antenatal ultrasound determination of chorionicity in twin pregnancy was undertaken at sub optimal period of gestation in over two thirds of twin pregnancies. Even in the first trimester of pregnancy, the accuracy of chorionicity determination was lower than previously reported.Item Impact of helminth infection on childhood allergic diseases in an area in transition from high to low infection burden(Asia Pacific Association of Allergy, Asthma and Clinical Immunology, 2012) Amarasekera, M.; Gunawardena, N.K.; de Silva, N.R.; Douglass, J.A.; O Hehir, R.E.; Weerasinghe, A.BCKGROUND: The effect of helminth infections on allergic diseases is still inconclusive. Furthermore, the effect of helminth infections on childhood allergic diseases in a tropical area where prevalence of helminth infections has undergone dramatic changes is not well documented. OBJECTIVE: To investigate the relationship between allergic diseases and helminth infection in a cohort of schoolchildren in an area that has undergone dramatic changes in intensity of helminth infections. METHODS: Children attending grade 5 were recruited from 17 schools in Western Province of Sri Lanka. They were assessed for allergic diseases using the International Study of Asthma and Allergies in Childhood questionnaire. Their serum total IgE (tIgE) and allergen-specific IgE (sIgE) for five common aeroallergens were measured by ImmunoCAP® method and stools were examined for the presence of helminth infections. RESULTS: A total of 640 children (mean age 10 years) were recruited to the study. Of them, 33.7% had evidence of allergic disease and 15.5% had helminth infections. Majority of infections (68.9%) were of low intensity. A significant relationship between allergic disease and helminth infections was not observed, however, a trend toward protective role of helminth infections against allergic diseases was noted. Multivariate analysis showed helminth infections to be an independent predictor of high tIgE levels whereas allergic disease was not. Allergic sensitization (atopy) was a significant risk factor for allergic disease only among non-infected children (odds ratio 3.025, p = 0.022) but not in infected children. The ratio of sIgE to tIgE was higher in non-infected children. CONCLUSION: Though not significant, a reduced risk of allergy in helminth-infected children was observed in this population. A Decrease in intensity of helminth infections may have contributed to the reduced capacity of immune-modulation by helminths in this paediatric population.