Medicine
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This repository contains the published and unpublished research of the Faculty of Medicine by the staff members of the faculty
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Item Unusual meuromuscular complications falciparum malaria(CAB International, 1994) de Silva, H.J.; de Silva, N.R.The involvement of the nervous system in Plasmodium falciparum malaria is a complex problem, and several mechanisms including mechanical obstruction of the microcirculation and immune mediated damage probably play a role in the pathogenesis. This review focuses attention on some of the more unusual neurological complications of falciparum malaria. Several neuropsychiatric manifestations have been reported during attacks of malaria and following use of antimalarial drugs.Item Immune activation during cerebellar dysfunction following Plasmodium falciparum malaria(Oxford University Press, 1992) de Silva, H.J.; Hoang, P.; Dalton, H.; de Silva, N.R.; Jewell, D.P.; Peiris, J.B.Evidence for immune activation was investigated in 12 patients with a rare syndrome of self-limiting, delayed onset cerebellar dysfunction following an attack of falciparum malaria which occurred 18-26 d previously. Concentrations of tumour necrosis factor, interleukin 6 and interleukin 2 were all significantly higher in serum samples of patients during cerebellar ataxia than in recovery sera and in the sera of 8 patients who did not develop delayed cerebellar dysfunction following an attack of falciparum malaria. Cytokine concentrations in the cerebrospinal fluid were also significantly higher in ataxic patients than in controls. These findings suggest that immunological mechanisms may play a role in delayed cerebellar dysfunction following falciparum malaria.