Medicine

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This repository contains the published and unpublished research of the Faculty of Medicine by the staff members of the faculty

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Start date: 1980End date: 1989

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Now showing 1 - 10 of 38
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    Psychiatric morbidity in 3 family practices
    (College of General Practitioners of Sri Lanka, 1989) Ferdinando, K.; de Silva, N*.; Wijegoonewardena, A.D.P.A.
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    Short-chain fatty acid irrigation in severe pouchitis
    (Massachusetts Medical Society, 1989) de Silva, H.J.; Ireland, A.; Kettlewell, M.; Mortensen, N.; Jewell, D.P.
    No Abstract available
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    Albendazole in the treatment of goehelminth infections in children
    (Sri Lanka Medical Association, 1989) de Silva, D.G.H.; Hettiarachchi, S.P.; Fonseka, P.H.
    Children with mixed helminthic infections between the ages of 2 and 14 years, from a slum area, were treated with two regimes of albendazole. A majority of children had moderate to heavy infections with Trichuris trichiura (greater than 70%) and Ascaris lumbricoides (greater than 84%). Children treated with a single 400 mg dose of albendazole showed a very good response in ascariasis with 100% cure rate irrespective of the severity of infection. In Trichuriasis (n = 40), a cure rate of 50% was observed in mild infections, but only a reduction in the egg counts of 60% and 57% respectively were observed in moderate and heavy infections. Only 10 patients with Necator americanus infections were treated with the single dose, and the cure rate in mild infections was satisfactory (86%), with an overall egg reduction rate of 95%. In 47 children included in the multiple dose regime (200 mg daily x 3 days), the cure rates in trichuriasis were, 82%, 66%, and 37% respectively in mild, moderate, and heavy infections. The egg reduction rate was 98% in all degrees of infection in trichuriasis. The cure rate in ascariasis, with the multiple dose regime was similar to that of the single dose, with 100% egg reduction, irrespective of the severity of infection.
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    Alteration in Aedes togoi susceptibility to Brugia pahangi microfilariae induced by Aedes albopictus thoracic homogenate
    (SEAMEO Regional Tropical Medicine and Public Health Project, 1989) Abeyewickreme, W.; Sucharit, S.; Choochote, W.; Chaicumpa, W.; Tumrasavin, W.
    Refractoriness to Brugia pahangi microfilarial infection could be induced in the normally susceptible Aedes togoi mosquitoes by intrathoracic injection with crude thoracic homogenate of the refractory Aedes albopictus mosquitoes. The crude thoracic homogenate contained three Sephadex G-200 protein profiles of which the first profile showed strongest inhibition to the parasite development.
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    A Preliminary investigation of the possible hypoglycaemic activity of Asteracanthus longifolia
    (Elsevier, 1989) Fernando, M.R.; Wickramasinghe, N.; Thabrew, M.I.; Karunanayaka, E.H.
    Investigations were carried out to confirm or otherwise disprove the view held by many Ayurvedic and other traditional medical practitioners in Sri Lanka, that Asteracanthus longifolia possesses hypoglycaemic properties. The effects of an aqueous extract of the whole plant on fasting blood glucose level and glucose tolerance were investigated using Sprague-Dawley rats. The results indicate that aqueous extracts of A. longifolia can significantly lower the fasting blood glucose level and markedly improve the glucose tolerance of the rats. The hypoglycaemic effect produced by a therapeutic dose (equivalent to 5 g/kg of starting material) was comparable to that produced by a therapeutic dose (15 mg/kg of tolbutamide. The magnitude of the hypoglycaemic effect was found to vary with the dosage administered and the storage time of the prepared extract.
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    An Evaluation of the potency of Osbeckia octandra and Melothria maderaspantana as antihepatotoxic agents.
    (George Thieme, 1989) Jayathilake, K.A.; Thabrew, M.I.; Pathirana, C.; de Silva, D.G.H.; Perera, D.J.
    Aqueous extracts of the aerial parts of Melothria maderasptana and the leaves of Osbeckia octandra have been compared with (+)-3-cyanidanol with regard to their abilities to alleviate carbon tetrachloride (CCl4)-induced liver dysfunction in albino rats by comparing the abilities of these drugs to protect the liver against CCl4-mediated alterations in the liver histopathology and serum levels of aspartate aminotransferase (GOT), alkaline amino-transferase (GPT), and alkaline phosphatase. In both pretreatment and post-treatment (administration of drugs before or after CCl4 treatment) experiments, the most marked rate of recovery of the liver was exhibited by the group of rats treated with Melothria maderaspatana extract. Although the protection offered by (+)-3-cyanidanol and Osbeckia octandra appears to be comparable in post-treatment, Osbeckia was significantly more effective in pre-treatment. From the overall results obtained it appears that the aqueous extracts of Melothria maderaspatana and Osbeckia octandra are both as potent or in some instances (in pretreatment experiments) more potent than (+)-3-cyanidanol. Of the two plants tested under the present experimental conditions used, Melothria maderaspatana appears to be marginally more effective than Osbeckia octandra in protecting the liver against CCl4-induced alterations.
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    The Association of autoimmune disorders with inflammatory bowel disease
    (Oxford University Press, 1989) Snook, J.A.; de Silva, H.J.; Jewell, D.P.
    Medical records of patients with ulcerative colitis (n = 858), Crohn's disease (n = 378) and coeliac disease (n = 148) were examined to determine the prevalence of associated autoimmune disorders. Of outpatient controls (n = 300), 2 per cent had at least one autoimmune disorder, compared to 7 per cent with ulcerative colitis, 2 per cent with Crohn's disease and 6 per cent with coeliac disease. Inclusion of primary sclerosing cholangitis with the autoimmune disorders increased the overall prevalence in ulcerative colitis to over 9 per cent. The results provide further indirect evidence of involvement of autoimmune mechanisms in the pathogenesis of ulcerative colitis
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    Skeletal muscle necrosis in severe falciparum malaria
    (British Medical Association, 1988) de Silva, H.J.; Goonetilleke, A.K.; Senaratna, N.; Ramesh, N.; Jayawickrama, U.S.; Jayasinghe, K.S.; Amarasekera, L.R.
    No Abstract Available
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    Stroke prevention : current trends
    (Ceylon College of Physicians, 1988/89) Gunatilake, S.B.
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    Sero-negative rheumatoid arthritis in haemoglobin E thalassaemia
    (Sri Lanka Medical Association, 1988) de Silva, H.J.; Senaratne, N.L.; Goonetilleke, A.K.; de Silva, C.; Jayawickrama, U.S.; Amarasekera, L.R.
    No Abstract Available
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